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Central Nervous System Stimulants: Historical Aspects and Clinical Effects

  • Chapter
Stimulants

Part of the book series: Handbook of Psychopharmacology ((SIBN,volume 11))

Abstract

The effects of central stimulants were identified early in the history of mankind; plants containing these substances are among the most ancient of known drugs. The use of ma huang (Ephedra vulgaris) in China, khat (Catha edulis) in Africa, and coca (Erythroxylon coca) in South America are examples of this early recognition. Thus, the Chinese herb ma huang, of acknowledged central stimulating activity, had been in use as a circulatory stimulant, diaphoretic, antipyretic, and antitussive agent (Chen and Schmidt, 1925) for some 5100 years before its main active ingredient, the sympathomimetic ephedrine, was introduced into clinical practice in the West for the treatment of asthma and similar conditions.

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Authors and Affiliations

  1. Neuropsychopharmacology Research Unit, Department of Psychiatry, New York University Medical Center, New York, New York, USA

    Burton Angrist & Abraham Sudilovsky

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  1. Burton Angrist
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  2. Abraham Sudilovsky
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  1. Department of Pharmacology, University of Cambridge, UK

    Leslie L. Iversen

  2. Department of Psychology, University of Cambridge, UK

    Susan D. Iversen

  3. Departments of Pharmacology and Psychiatry, School of Medicine, The Johns Hopkins University, USA

    Solomon H. Snyder

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© 1978 Plenum Press, New York

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Angrist, B., Sudilovsky, A. (1978). Central Nervous System Stimulants: Historical Aspects and Clinical Effects. In: Iversen, L.L., Iversen, S.D., Snyder, S.H. (eds) Stimulants. Handbook of Psychopharmacology, vol 11. Springer, Boston, MA. https://doi.org/10.1007/978-1-4757-0510-2_3

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  • DOI: https://doi.org/10.1007/978-1-4757-0510-2_3

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