Intracellular Events in Prolactin Secretion

  • Antonia Zanini
  • Giuliana Giannattasio
  • Jacopo Meldolesi
Part of the Biochemical Endocrinology book series (BIOEND)


Considerable experimental evidence, obtained during the last several years, indicates that secretion of prolactin (PRL) is carried out in pituitary mammotrophs by means of a series of complex interconnected events(analogous to those occurring in other protein-secreting cells) that ultimately result in hormone discharge by exocytosis (Fig. 1). This chapter will focus primarily on one such event, namely, the packaging of PRL within secretion granules. The others, namely, the biosynthesis of the hormone and its transport to the Golgi periphery, exocytosis, and crino-phagy, as well as the recycling of membranes from the cell surface, will be dealt with only briefly, because they have been covered in detailed reviews that have been published recently or will appear soon (Farquhar et al., 1975; Pälade, 1975; Farquhar, 1977; Meldolesi et al., 1978; De Camilli et al., 1979; Herzog and Miller, 1979). In addition, specific problems related to these events are discussed in other chapters of this volume.


Rough Endoplasmic Reticulum Golgi Complex Prolactin Secretion Intracellular Event Granule Membrane 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Antonia Zanini
    • 1
  • Giuliana Giannattasio
    • 1
  • Jacopo Meldolesi
    • 1
  1. 1.Department of Pharmacology and CNR Center of CytopharmacologyUniversity of MilanMilanItaly

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