Functional Heterogeneity of Separated Dispersed Gonadotropic Cells

  • Carl Denef
Part of the Biochemical Endocrinology book series (BIOEND)


It is well documented that the gonadotropic cell population of the pituitary gland is morphologically heterogeneous. Histochemical staining reactions (Herlant, 1960, 1964) and electron-microscopic examinations (Farquhar and Rinehart, 1954; Barnes, 1962; Yoshimura and Harumiya, 1965; Kurosumi and Oota, 1968) have revealed the presence of two different cell types. One contained two populations of secretory granules the size of which was about 200 and 700 nm, respectively, and was believed to secrete follicle-stimulating hormone (FSH). The other was smaller, contained only one type of secretory granules with a size of 250 nm, and was thought to secrete luteinizing hormone (LH). However, after immuno-chemical methods became available to demonstrate directly the hormones in the cell, it became evident that there was no separate location of the two gonadotropins in a given cell type (see the review by Girod, 1977). Several investigators showed that each of these cell types was immuno-reactive to anti-LH antiserum (Tougard et al., 1973; Moriarty, 1975) as well as to anti-FSH antiserum (Tixier-Vidal et al., 1975b; Moriarty, 1976).


Luteinizing Hormone Follicle Stimulate Hormone Pituitary Cell Anterior Pituitary Cell Functional Heterogeneity 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Carl Denef
    • 1
  1. 1.Laboratory of Cell Pharmacology, Department of Pharmacology, School of Medicine, Campus GasthuisbergKatholieke Universiteit LeuvenLeuvenBelgium

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