The Pattern of LH Release of Rat Pituitary Glands during Long-Term Exposure to LH-RH in Vitro
During continuous exposure of pituitary glands of intact rats to synthetic luteinizing hormone-releasing hormone (LH-RH) in vitro (de Koning et al., 1976a,b, 1978a) and in vivo (Schuiling and Zürcher, 1975; Blake, 1976; Vilchez-Martinez et al., 1976; Schuiling et al., 1976), three phases in the luteinizing hormone (LH)-releasing patterns can be distinguished. Initially, the rate of LH release is low and constant; next, it increases progressively, and then it declines. In the LH-releasing patterns of pituitary glands of ovariectomized (OVX) rats, the initial phase is absent in vitro (Jutisz et al, 1975; Osland et al., 1975; de Koning et al., 1976a,b, 1978a) as well as in vivo (Schuiling and Gnodde, 1976, 1977).
KeywordsLuteinizing Hormone Pituitary Gland Protein Factor Luteinizing Hormone Surge Estradiol Benzoate
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