Pituitary Polypeptide-Secreting Cells: Immunocytochemical Identification of ACTH, MSH, and Peptides Related to LPH

  • G. Tramu
  • J. C. Beauvillain
Part of the Biochemical Endocrinology book series (BIOEND)


Until recently, the anterior lobe of the hypophysis was thought to be responsible for corticotropin (ACTH) elaboration, while melanotropin(MSH) secretion was attributed to the intermediate lobe. Other results, however, have indicated a relationship between the intermediate lobe and corticotropic function. The possibility of corticotropic activity of the neurointermediate lobe had been underlined by Mialhe-Voloss (1958), and Rochefort et al. (1959) also came to similar conclusions. Gosbee et al.(1970) showed that the intermediate lobe could be changed morphologically by adrenalectomy and concluded that it is implicated in functional ACTH production. Other results indicated the presence of cells in the rostral portion of the intermediate lobe that were morphologically identical to anterior-lobe ACTH cells (Porte et al., 1971; Stoeckel et al., 1971). Furthermore, Kraicer et al. (1971) have demonstrated the presence of ACTH in isolated intermediate lobes, in even greater quantities than in the anterior lobe.


Anterior Lobe Intermediate Lobe ACTH Molecule ACTH Sequence Neurointermediate Lobe 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • G. Tramu
    • 1
  • J. C. Beauvillain
    • 1
  1. 1.Laboratory of Histology, Faculty of MedicineU. 156 I.N.S.E.R.M.LilleFrance

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