Interaction of Glucocorticoids, CRF, and Vasopressin in the Regulation of ACTH Secretion

  • B. Koch
  • B. Lutz-Bucher
  • C. Mialhe
Part of the Biochemical Endocrinology book series (BIOEND)


The rate of secretion of pituitary corticotropin (ACTH) is regulated by a hypothalamic neurohormone (or hormones), which in turn is known to be under control of higher centers of the brain through the link of the action of neurotransmitters (Van Loon, 1973; Jones et al., 1976). Moreover, unlike hormones such as growth hormone or prolactin, the secretion of which depends on both excitatory and inhibitory hypothalamic factors, ACTH release appears to be primarily modulated by glucocorticoids exerting negative-feedback effects at the hypothalamic as well as the pituitary level.


Anterior Pituitary Gland Pituitary Cell Scatchard Plot ACTH Secretion ACTH Release 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • B. Koch
    • 1
  • B. Lutz-Bucher
    • 1
  • C. Mialhe
    • 1
  1. 1.Institut de PhysiologieUniversité Louis PasteurStrasbourgFrance

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