Mechanism of Action of Hypothalamic Hormones and Interactions with Sex Steroids in the Anterior Pituitary Gland

  • Fernand Labrie
  • Pierre Borgeat
  • Martin Godbout
  • Nicholas Barden
  • Michèle Beaulieu
  • Lisette Lagacé
  • Jocelyne Massicotte
  • Raymonde Veilleux
Part of the Biochemical Endocrinology book series (BIOEND)


Although peripheral hormones have been shown for many years to play a major role in the control of adenohypophyseal activity in man and experimental animals, in vivo approaches could not distinguish between hypothalamic and pituitary sites of action. This area of research has been much facilitated by the development of the pituitary cell culture system(Vale et al., 1972; Labrie et al., 1973). In fact, adenohypophyseal cells in primary culture have been extremely useful not only for assessment of the biological activity of analogues of thyrotropin-releasing hormone (TRH), luteinizing hormone-releasing hormone (LH-RH), and somatostatin (La-brie et al., 1973, 1976a, b; Belanger et al., 1974), but also for determination of the characteristics of interaction between hypothalamic and peripheral hormones at the adenohypophyseal level (Drouin et al., 1976a,b; Drouin and Labrie, 1976a, b).


Prolactin Secretion Anterior Pituitary Cell Prolactin Release Estradiol Benzoate Pituitary Level 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Fernand Labrie
    • 1
  • Pierre Borgeat
    • 1
  • Martin Godbout
    • 1
  • Nicholas Barden
    • 1
  • Michèle Beaulieu
    • 1
  • Lisette Lagacé
    • 1
  • Jocelyne Massicotte
    • 1
  • Raymonde Veilleux
    • 1
  1. 1.Medical Research Council Group in Molecular EndocrinologyLe Centre Hospitalier de l’Université LavalQuebecCanada

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