Hormonal Regulation of Prolactin mRNA

  • Glen A. Evans
  • Michael G. Rosenfeld
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

The neuroendocrine regulation of pituitary hormone synthesis and secretion is a complex process in which polypeptide hormones, bioamines, and steroid hormones play a part. Various hormones have been documented to exert stimulatory or inhibitory effects on the biosynthesis and secretion of specific pituitary hormones. The molecular processes underlying these hormonally induced alterations are less well understood, but current data suggest that significant differences may exist in the actions of steroid and polypeptide hormones at the molecular level.

Keywords

Estrogen Hydrocortisone Polypeptide Prostaglandin Methotrexate 

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References

  1. Alt, F. W., Kellems, R. E., Bertino, J. R., and Schimke, R. T., 1978, Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells, J. Biol. Chem. 253: 1357.PubMedGoogle Scholar
  2. Blobel, G., and Dobberstein, B., 1975, Transfer of proteins across membranes: Presence of proteolytically processed and unprocessed nascent immunoglobulin light chains on membrane-bound ribosomes of murine myeloma, J. Cell Biol. 67: 835.PubMedCrossRefGoogle Scholar
  3. Brown, D. D., and Dawid, J. B., 1968, Specific gene amplification in oocytes, Science 160: 272.PubMedCrossRefGoogle Scholar
  4. Dannies, P. S., and Tashjian, A. H., 1976, TRH increases prolactin mRNA activity in the cytoplasm of GH cells as measured by translation in a wheat germ cell-free system, Biochem. Biophys. Res. Commun. 70: 1180.PubMedCrossRefGoogle Scholar
  5. Dannies, P. S., Yen, P. M., and Tashjian, A. H., Jr., 1977, Anti-estrogenic compounds increase prolactin and growth hormone synthesis in clonal strains of rat pituitary cells, Endocrinology 101: 1151.PubMedCrossRefGoogle Scholar
  6. Evans, G. A., and Rosenfeld, M. G., 1976, Cell-free synthesis of a prolactin precursor directed by mRNA from cultured rat pituitary cells, J. Biol. Chem. 251: 2842.PubMedGoogle Scholar
  7. Evans, G. A., and Rosenfeld, M. G., 1979, Regulation of prolactin mRNA analyzed using a specific cDNA probe, J. Biol. Chem. 254: 8023.PubMedGoogle Scholar
  8. Evans, G. A., Hucko, J., and Rosenfeld, M. G., 1977, Preprolactin represents the initial product of prolactin mRNA translation, Endocrinology 101: 1807.PubMedCrossRefGoogle Scholar
  9. Evans, G. A., David, D. N., and Rosenfeld, M. G., 1978, Regulation of prolactin and somatotropin mRNAs by thyroliberin, Proc. Natl. Acad. Sci. U.S.A. 75: 1294.PubMedCrossRefGoogle Scholar
  10. Gautvik, K. M., and Kriz, M., 1976, Effects of prostaglandins on prolactin and growth hormone synthesis and secretion in cultured rat pituitary cells, Endocrinology 98: 352.PubMedCrossRefGoogle Scholar
  11. Hayashi, I., and Sato, G. H., 1976, Replacement of serum by hormones permits growth of cells in a defined medium, Nature (London) 259: 132.CrossRefGoogle Scholar
  12. Lingappa, V. R., Devillers-Thiery, A., and Blobel, G., 1977, Nascent prehormones are intermediates in the biosynthesis of authentic bovine pituitary growth hormone and prolactin, Proc. Natl. Acad. Sci. U.S.A. 74: 2432.PubMedCrossRefGoogle Scholar
  13. Mains, R. E., and Eipper, B. A., 1976, Biosynthesis of adrenocorticotropic hormone in mouse pituitary tumor cells, J. Biol. Chem. 251: 4115.PubMedGoogle Scholar
  14. Martin, T. F. J., and Tashjian, A. H., Jr., 1977, Cell culture studies of thyrotropin-releasing hormone action, in: Biochemical Actions of Hormones, Vol. IV (G. Litwack, ed.), pp. 270–312, Academic Press, New York.Google Scholar
  15. Maurer, R. A., Stone, R., and Gorski, J., 1976, Cell-free synthesis of a large translation product of prolactin mRNA, J. Biol. Chem. 251: 2801.PubMedGoogle Scholar
  16. Maurer, R. A., Gorski, J., and McKean, D. J., 1977, Partial amino acid sequence of rat pre-prolactin, Biochem. J. 161: 189.PubMedGoogle Scholar
  17. Monahan, J. J., Harris, S. E., and O’Malley, B. W., 1977, Analysis of cellular messenger RNA using complementary DNA probes, in: Receptors and Hormone Action, Vol. I (B. W. O’Malley and L. Birnbaumer, eds.), pp. 297–329, Academic Press, New York.Google Scholar
  18. Old, J., Clegg, J. B., Weatherall, D. J., Ottolenghi, S., Comi, P., Giglioni, B., Mitchell, J., Tolstoshev, P., and Williamson, R., 1976, A direct estimate of the number of human γ-globin genes, Cell 8: 13.PubMedCrossRefGoogle Scholar
  19. O’Farrell, P. H., 1975, High resolution two-dimensional electrophoresis of proteins, J. Biol. Chem. 250: 4007.PubMedGoogle Scholar
  20. Roberts, J. C., and Herbert, E., 1977, Characterization of a common precursor to corticotropin and β-lipotropin: Identification of β-lipotropin peptides and their arrangement relative to corticotropin in the precursor synthesized in a cell-free system, Proc. Natl. Acad. Sci. U.S.A. 74: 5300.PubMedCrossRefGoogle Scholar
  21. Rogol, A. D., and Chrambach, A., 1975, Radioiodinated human pituitary and amniotic fluid prolactins with preserved molecular integrity, Endocrinology 97: 406.PubMedCrossRefGoogle Scholar
  22. Shome, B., and Parlow, A. F., 1977, Human pituitary prolactin: The entire linear amino acid sequence, J. Clin. Endocrinol. Metab. 45: 1112.PubMedCrossRefGoogle Scholar
  23. Sonnenschein, C., Richardson, U. I., and Tashjian, A. H., Jr., 1970, Chromosomal analysis, organ-specific function and appearance of six clonal strains of rat pituitary tumor cells, Exp. Cell Res. 61: 121.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Glen A. Evans
    • 1
  • Michael G. Rosenfeld
    • 1
  1. 1.Division of Endocrinology, Department of MedicineUniversity of California, San Diego, School of MedicineLa JollaUSA

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