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Effect of TRH on the Synthesis and Stability of Cytoplasmic RNAs of GH3B6 Cells

  • A. Morin
Part of the Biochemical Endocrinology book series (BIOEND)

Abstract

Rat prolactin continuous cell lines offer invaluable models for studying the mechanism of action of thyroliberin (TRH) on prolactin (PRL) secretion in a homogeneous population of target cells (Tashjian and Hoyt, 1972; Tixier-Vidal et al., 1975). One of these cell lines, GH3B6, is a subclone of the GH3 strain derived from a transplantable pituitary tumor induced by chronic estrogen treatment (Tashjian et al., 1968). As reported by Tashjian et al. (1970, 1971) and Gourdji et al. (1972) for GH3 cells, GH3B6 cells secrete both PRL and, at a low level, growth hormone (GH), and they respond to TRH by an increase of PRL secretion.

Keywords

Growth Hormone Cytoplasmic RNAs Chase Experiment Prolactin mRNA Cytoplasmic Poly 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • A. Morin
    • 1
  1. 1.Groupe de Neuroendocrinologie Cellulaire, Laboratoire de Physiologie CellulaireCollège de FranceParis 05France

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