Biosynthesis of β-Endorphin in the Rat Pars Intermedia

  • P. Crine
  • F. Gossard
  • N. G. Seidah
  • C. Gianoulakis
  • M. Lis
  • M. Chrétien
Part of the Biochemical Endocrinology book series (BIOEND)


β-Lipotropin (β-LPH) is a 91-amino-acid pituitary peptide the biological importance of which has remained obscure for a long time except for a role as a prohormone. It was discovered and isolated in 1964 from sheep pituitary glands by Li (1964) and Birk and Li (1964). As a fat-mobilizing agent, β-LPH is most active in rabbit adipose tissue, only weakly active in rat, and essentially inactive in mouse (Lohmar and Li, 1967). This lipolytic activity, however, has not been a specific property of lipotropin, since α-melanocyte-stimulating hormone (α-MSH) and β-MSH are 100 times more active. In fact, almost all the hormones from the anterior pituitary show some lipolytic action besides their main biological function.


Pituitary Gland Butyl Chloride Citraconic Anhydride Radioactive Amino Acid Pituitary Peptide 


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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • P. Crine
    • 1
  • F. Gossard
    • 1
  • N. G. Seidah
    • 1
  • C. Gianoulakis
    • 1
  • M. Lis
    • 1
  • M. Chrétien
    • 1
  1. 1.Clinical Research Institute of MontrealMontrealCanada

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