Changes in the Responsiveness to LH-RH in FSH-Treated 4-Day Cycling Female Rats

  • Jean-Marie Geiger
Part of the Biochemical Endocrinology book series (BIOEND)


Previous work (Chateau, 1971) showed that FSH treatment at the onset of 4-day cycles caused an increased number of follicles to develop until the stage of proestrus with respect to untreated control females. FSH treatment also induced the rupture of an excessive number of follicles (superovula-tion) and the formation of a great number of corpora lutea with included oocytes (superluteinization). No changes in the timing of the “critical period” of the cycle were observed during the afternoon of proestrus(Geiger and Chateau, 1976). However, LH and FSH surges appeared to be decreased compared to control females (Geiger and Plas-Roser, 1976). Our aim was, then, to determine whether this decline in gonadotropin release was related to changes in the pituitary responsiveness to LH-RH. The study presented in this chapter was also designed to compare plasma estradiol-17β concentration in FSH-treated and nontreated control females.


Luteinizing Hormone Pituitary Gland Luteinizing Hormone Release Estradiol Benzoate Pituitary Responsiveness 
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Copyright information

© Springer Science+Business Media New York 1980

Authors and Affiliations

  • Jean-Marie Geiger
    • 1
  1. 1.Institut d’HistologieFaculté de MédecineStrasbourgFrance

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