Immunochemical Characterization of Syrian Hamster Major Histocompatibility Complex Homologues
The genes within the chromosomal segment known as the major histocompatibility complex (MHC) encode products that enable immunologic communication among cells and promote self-versus-nonself recognition—capabilities considered vital to every mammalian species (1). Generalizations of the mechanisms involved in MHC function are derived from studies performed in various animal models (1,2). Historically, the Syrian hamster has been considered unique with regard to certain MHC-mediated phenomena. Abnormal structure and/or expression of hamster MHC products have been suggested to account for certain of these features (3–5). To investigate these alternatives, cell-surface molecules putatively homologous to MHC products of other species have been identified and immunochemically characterized in the Syrian hamster (6–8). The possible relationships between these homologues and newly defined hamster cell-surface alloantigens are considered in this study.
KeywordsSyrian Hamster Antigen Preparation Hamster Cheek Pouch Hamster Strain IMMUNOCHEMICAL Characterization
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