Allergic Contact Dermatitis in the Hamster and in Other Rodents

  • Henry C. MaguireJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 134)


The first, and for a long time the only, experimental animal for the study of allergic contact dermatitis (ACD) was the guinea pig (1). Thus the basic studies that related sensitization potential to the ability of a low molecular weight allergen to couple to protein, that established the requirement for viable lymphoid cells (not sera) for the passive transfer of hypersensitivity to simple chemical allergens, and that demonstrated the induction of a specific immunological unresponsiveness to contact allergens, were done in the guinea pig (2,3, 4,5). Indeed, the guinea pig still remains the animal of choice for the identification of contact allergens of man (6,7). In 1968, the technique of measuring increased ear thickness as a way of assessing induced inflammation by contact allergens in the mouse was introduced (8); in contrast to the guinea pig, inflammatory skin reactions on the flank of the mouse are difficult to evaluate since these reactions lack both erythema and easily defined induration. The ear thickness technique recently has been extended to studies of allergic contact dermatitis in the hamster (9,10) and we are using the same methodology to evaluate ACD hypersensitivity in rats (11). This report examines ACD in the hamster and relates it to ACD in other species.


Allergic Contact Dermatitis Positive Control Group Flare Reaction Toxicity Control Challenge Site 


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  1. 1.
    Chase, M.W. Harvey Lectures, Series 61, pp. 169-203 (1965-1966) Academic Press (1967).Google Scholar
  2. 2.
    Landsteiner, K.; Jacob, J. J Exp Med 61 (1935) 643.PubMedCrossRefGoogle Scholar
  3. 3.
    Landsteiner, K.; Chase, M.W. Proc Soc Exp Biol Med 49 (1942) 688.Google Scholar
  4. 4.
    Sulzberger, M.B. Arch Dermatol Syph 20 (1929) 669.CrossRefGoogle Scholar
  5. 5.
    Chase, M.W. Proc Soc Exp Biol Med 61 (1946) 257.PubMedGoogle Scholar
  6. 6.
    Magnusson, B.; Kligman, A.M. Allergic Contact Dermatitis in the_Guinea Pig; Identification of Contact Allergens. Charles C. Thomas, Springfield, Ill. (1970).Google Scholar
  7. 7.
    Maguire, H.C. Jr. Animal Models in Dermatology, ed. Maibach. Churchill-Livingston, New York (1975) 67.Google Scholar
  8. 8.
    Asherson, G.L.; Ptak, W. Immunology 15 (1968) 405.PubMedGoogle Scholar
  9. 9.
    Magure, H.C, Jr. Fed Proc 38 (1979) 1173 (Abst #4996).Google Scholar
  10. 10.
    Streilein, J. W. et al. J. Immunol 124 (1980) 577.PubMedGoogle Scholar
  11. 11.
    Jaffee, B.; Maguire, H.C. Jr. Allergic Contact Dermatitis in the Rat (in preparation).Google Scholar
  12. 12.
    Maguire, H.C. Jr.; Chase, M.W. J Exp Med 135 (1972) 357.PubMedCrossRefGoogle Scholar
  13. 13.
    Maguire, H.C. Jr. Immunol Commun 1 (1972) 239.PubMedGoogle Scholar
  14. 14.
    Maguire, H.C. Jr.; Maibach, H.I. J Allergy 32 (1961) 406.PubMedCrossRefGoogle Scholar
  15. 15.
    Santos, G.W. Fed Proc 26 (1967) 907.PubMedGoogle Scholar
  16. 16.
    Maguire, H.C. Jr.; Ettore, V.L. J Invest Dermatol 48 (1967) 39.PubMedGoogle Scholar
  17. 17.
    Hunziger, N. Dermatologica 135 (1968) 187.CrossRefGoogle Scholar
  18. 18.
    Turk, J.L. et al. Immunology 23 (1972) 493.PubMedGoogle Scholar
  19. 19.
    Lagrange, P.W. et al. J Exp Med 139 (1974) 1529.PubMedCrossRefGoogle Scholar
  20. 20.
    Easmon, C.S.F.; Glynn, A.A. Immunology 33 (1977) 767.PubMedGoogle Scholar
  21. 21.
    Finerty, J.H. Fed Proc 34 (1975) 1025 (Abst. #4568).Google Scholar
  22. 22.
    Kerckhaert, J.A.M. et al. J Immunol 113 (1974) 180.Google Scholar
  23. 23.
    Yoshida, S. et al. Clin Exp Immunol 38 (1979) 211.PubMedGoogle Scholar
  24. 24.
    Maguire, H.C Jr. et al. Proc Am Assoc Cancer Res 21 (1980) 203 (Abst. #814).Google Scholar
  25. 25.
    Maguire, H.C Jr. et al. Immunology 37 (1979) 367.PubMedGoogle Scholar
  26. 26.
    Frei, W. Klin Wochenschr 7 (1928) 539.CrossRefGoogle Scholar
  27. 27.
    Claman, H.N.; Moorhead, J.W. Contemp Top Immunobiol 5 (1976) 211.PubMedGoogle Scholar
  28. 28.
    Maguire, H.C Jr.; Weidanz, W.P. Clin Res 28 (1980) 574A.Google Scholar
  29. 29.
    Turk, J.L. Immunology 5 (1962) 478.PubMedGoogle Scholar
  30. 30.
    Kay, K.; Rieke, W.O. Science 139 (1963) 487.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Henry C. MaguireJr.
    • 1
  1. 1.Division of DermatologyHahnemann Medical CollegePhiladelphiaUSA

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