C-Type Particles in Thymic Development: A Correlation with Thymic Function
Endogenous C-type retroviruses are expressed morphologically and antigenically in embryos of many mammalian species (1,2). Viral DNA is inserted into the host genome and thus can be vertically transmitted from parent to offspring. In addition, the expression of these viruses is highly regulated by host genes (1). In both inbred and feral mice, C-type particles are seen consistently in developing lymphoid organs during fetal life, but disappear prior to birth (3,4). It has been reported (5) that in fetal murine thymus, C-type particles are first seen budding from reticular epithelial cells and later from thymocytes. Consequently, it has been suggested that the expression of these particles may play a role in the differentiation of normal T lymphocytes.
KeywordsSyrian Hamster Adult Morphology Mouse Thymus Thymic Development Thymic Lobe
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