C-Type Particles in Thymic Development: A Correlation with Thymic Function

  • Pamela L. Witte
  • J. Wayne Streilein
  • W. A. ShannonJr.
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 134)


Endogenous C-type retroviruses are expressed morphologically and antigenically in embryos of many mammalian species (1,2). Viral DNA is inserted into the host genome and thus can be vertically transmitted from parent to offspring. In addition, the expression of these viruses is highly regulated by host genes (1). In both inbred and feral mice, C-type particles are seen consistently in developing lymphoid organs during fetal life, but disappear prior to birth (3,4). It has been reported (5) that in fetal murine thymus, C-type particles are first seen budding from reticular epithelial cells and later from thymocytes. Consequently, it has been suggested that the expression of these particles may play a role in the differentiation of normal T lymphocytes.


Syrian Hamster Adult Morphology Mouse Thymus Thymic Development Thymic Lobe 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Pamela L. Witte
    • 1
    • 2
  • J. Wayne Streilein
    • 1
    • 2
  • W. A. ShannonJr.
    • 1
    • 2
  1. 1.Department of Cell BiologyUniversity of Texas Health Science Center at DallasDallasUSA
  2. 2.Veterans Administration HospitalDallasUSA

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