An Immune- and Hormone-Dependent Phase During the Latency Period of SV40 Oncogenesis in Syrian Hamsters
SV40 oncogenesis in hamsters requires a latency period ranging from three to more than 12 months. Hamsters neonatally inoculated with SV40 do not develop tumors until much later, as adults, but then the incidence of tumor-bearing hamsters is very high (1). During this latency period, the hamsters appear to be immunologically neutral to SV40 or SV40-TSTA; they are neither tolerant nor resistant, and tumor induction can be prevented by specific immunization with the virus or the tumor cells up until a few weeks before the tumor becomes palpable (2,3).
KeywordsLatency Period Host Animal Graft Recipient Testosterone Propionate Cortisone Acetate
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