Effect of Vaccinia-Activated Macrophages on Scrapie Infection in Hamsters
The Syrian hamster has been shown to be the animal model of choice for studies on the physicochemical nature of the scrapie agent (1). The high titers of scrapie infectivity in brain tissue and the short incubation periods in this species have decreased the time required to obtain bioassay data necessary for the detection of this unusual neuropathic agent. Relatively little attention, however, has been given to the pathogenesis of scrapie infection in the hamster. The main purpose of this study was to investigate the role of the macrophage on early events in hamsters inoculated intraperitoneally (IP) with the hamster-adapted scrapie agent.
KeywordsMinimal Essential Medium Vaccinia Virus Saline Control Syrian Hamster Nonadherent Cell
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