Susceptibility to Fatal Pichinde Virus Infection in the Syrian Hamster

  • Sydney R. Gee
  • Marcia A. Chan
  • David A. Clark
  • William E. Rawls
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 134)


Pichinde virus, an arenavirus, causes a fatal infection in the inbred MHA strain of Syrian hamsters within 10 to 20 days of an intraperitoneal inoculation (1). High titres of virus are present, and death appears to be a direct consequence of the virus-induced necrosis in cells of the liver and spleen (2). Other strains of hamsters, including the inbred LSH strain and the random-bred LVG line, survive the infection. Resistance to the fatal virus infection is associated with an ability to limit Pichinde virus replication to low levels. The phenotypes of survival and the ability to limit viremia are each controlled by a single dominant gene (3, 4); it is not known whether the same gene controls both properties. Since the pathogenesis of Pichinde virus infection in Syrian hamsters resembles the pathogenesis of human arenavirus infections in several respects (5), an understanding of the events leading to the recovery of hamsters from Pichinde virus disease may contribute some insight into the factors controlling the human diseases. In this paper, early events of Pichinde virus infection and the immune response to the virus in the resistant and susceptible hamster strains are described.


Natural Killer Cell Spleen Cell Syrian Hamster Natural Killer Activity Popliteal Lymph Node 
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  1. 1.
    Buchmeier, M.J.; Rawls, W.E. Infect Immun 16 (1977) 413.PubMedGoogle Scholar
  2. 2.
    Murphy, F.A. et al. Lab Invest 37 (1977) 502.PubMedGoogle Scholar
  3. 3.
    Gee, S.R. et al. J Immunol 123 (1979) 2618.PubMedGoogle Scholar
  4. 4.
    Gee, S.R. et al. Academic Press (1980) in press.Google Scholar
  5. 5.
    Rawls, W.E.; Leung, W.-C. Comprehensive Virol 14 (1979) 157.CrossRefGoogle Scholar
  6. 6.
    Mifune, K. et al. Proc Soc Exp Biol Med 136 (1971) 637.PubMedGoogle Scholar
  7. 7.
    Paranjpe, M.S.; Boone, C.W. J Natl Cancer Inst 48 (1972) 563.PubMedGoogle Scholar
  8. 8.
    Stephen, E.L. et al. Texas Rep Biol Med 35 (1977) 449.Google Scholar
  9. 9.
    Oldstone, M.B.A. Comprehensive Virol 15 (1979) 1.CrossRefGoogle Scholar
  10. 10.
    Zinkernagel, R.M. et al. J Immunol 119 (1977) 1242.PubMedGoogle Scholar
  11. 11.
    Datta, S.K. et al. Int J Cancer 23 (1979) 728.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Sydney R. Gee
    • 1
  • Marcia A. Chan
    • 1
  • David A. Clark
    • 1
  • William E. Rawls
    • 1
  1. 1.McMaster University Health Sciences CentreHamiltonCanada

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