Experimental Subacute Sclerosing Panencephalitis (SSPE) in the Hamster

  • Kenneth P. Johnson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 134)


Experimental animal models that faithfully duplicate most aspects of a significant human disease have contributed greatly to the understanding of the condition in man. Experimental diseases produced in small animals also allow more comprehensive studies at less cost in that many more individuals can be investigated and significant variations in populations can be assessed. This is of major value in infectious diseases in which only a few animals may manifest significant changes. Experimental diseases, especially infectious ones, in animals are highly useful because a disease state can be studied in all its complexity only in the intact mammal. Thus, although important information can be gained from in vitro studies, ultimately the essential combination of genetic, immunological, dosage, and cell specificity factors can be assayed only in the intact animal, allowing a more complete understanding of the disease process to be unraveled.


Measle Virus Nucleocapsid Protein Subacute SCLEROSING Panencephalitis Measle Antibody Newborn Hamster 
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  1. 1.
    Agnarsdotter, G. In: Recent Advances in Clinical Virology, ed. Waterson. Churchhill Livingston Inc. London (1977) 21.Google Scholar
  2. 2.
    Norrby, E. Prog Med Virol 24 (1978) 1.PubMedGoogle Scholar
  3. 3.
    Johnson, K.P. et al. In: Advances in Neurology, ed. Thompson and Green, Vol. 6. Raven Press, New York (1974) 77.Google Scholar
  4. 4.
    Andriola, M.; Karlsberg, R.O. Am J Dis Child 124 (1972) 187.PubMedGoogle Scholar
  5. 5.
    Lennette, E.H. Arch Neurol 32 (1975) 488.CrossRefGoogle Scholar
  6. 6.
    Modlin, J.F. et al. J Ped 94 (1979) 231.CrossRefGoogle Scholar
  7. 7.
    Wear, D.; Rapp, F. J Immunol 107 (1971) 1593.PubMedGoogle Scholar
  8. 8.
    Norrby, E.; Kristensson, K. J Med Virol 2 (1978) 305.PubMedCrossRefGoogle Scholar
  9. 9.
    Norrby, E. et al. J Med Virol 5 (1980) 109.PubMedCrossRefGoogle Scholar
  10. 10.
    Byington, D.P.; Johnson, K.P. J Infect Dis 126 (1972) 18.PubMedCrossRefGoogle Scholar
  11. 11.
    Byington, D.P. et al. Nature 225 (1970) 551.CrossRefGoogle Scholar
  12. 12.
    Parhad, I.M. et al. Lab Invest, in press.Google Scholar
  13. 13.
    Johnson, K.P.; Byington, D.P. Exp Mol Pathol 15 (1971) 373.PubMedCrossRefGoogle Scholar
  14. 14.
    Raine, CS. et al. Lab Invest 33 (1975) 108.PubMedGoogle Scholar
  15. 15.
    Johnson, K.P.; Norrby, E. Exp Mol Pathol 21 (1974) 166.PubMedCrossRefGoogle Scholar
  16. 16.
    Raine, E.S. et al. Lab Invest 31 (1974) 355.PubMedGoogle Scholar
  17. 17.
    Johnson, K.P.; Swoveland, P. Lab Invest 37 (1977) 459.PubMedGoogle Scholar
  18. 18.
    Byington, D.P.; Johnson, K.P. Lab Invest 32 (1975) 91.PubMedGoogle Scholar
  19. 19.
    Johnson, K.P. et al. Infect Immun 12 (1975) 1464.PubMedGoogle Scholar
  20. 20.
    Morgan, E.M.; Rapp, F. Bacteriol Rev 41 (1977) 636.PubMedGoogle Scholar
  21. 21.
    Yoshida, T. et al. Virology 71 (1976) 143.PubMedCrossRefGoogle Scholar
  22. 22.
    Hall, W.W. et al. Proc Natl Acad Sci USA 76 (1979) 2047.PubMedCrossRefGoogle Scholar
  23. 23.
    Wechsler, S.L. et al. J Immunol 123 (1979) 884.PubMedGoogle Scholar
  24. 24.
    Machamer, C.E. et al. Infect Immun 27 (1980) 817.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Kenneth P. Johnson
    • 1
  1. 1.Neurology ServiceVeterans Administration Medical Center and the University of CaliforniaSan FranciscoUSA

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