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LSH Hamster Model of Syphilitic Infection and Transfer of Resistance with Immune T Cells

  • Ronald F. Schell
  • Jack L. LeFrock
  • John K. Chan
  • Omar Bagasra
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 134)

Abstract

The immunologic basis of host defense in syphilis has not been elucidated. The humoral immune response appears to afford only negligible protection. The disease progresses from a local lesion to secondary syphilis with 24% of patients developing relapsing secondary lesions despite the development of a vigorous antibody response. Passive immunization of rabbits or hamsters with immune serum (1–5) or immunoglobulin (6) has failed to prevent infection of animals with Treponema pallidum.

Keywords

Sheep Erythrocyte Secondary Syphilis Normal Hamster Syphilitic Infection Treponemal Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Ronald F. Schell
    • 1
  • Jack L. LeFrock
    • 1
  • John K. Chan
    • 1
  • Omar Bagasra
    • 1
  1. 1.Department of Medicine (Infectious Diseases)Hahnemann Medical College and HospitalPhiladelphiaUSA

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