Immune Response of the Hamster to Experimental Mycoplasma Pneumoniae Disease

  • Wallace A. ClydeJr.
  • Gerald W. Fernald
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 134)


The Syrian hamster (Mesocricetus auratus) first was used for experimental Mycoplasma pneumoniae infections soon after the introduction of this species as a laboratory animal in the United States. Isolation of an infectious agent from patients with atypical pneumonia by intranasal inoculation of cotton rats (Sigmodon hispidus) with sputum samples was reported in 1942. Although unsuccessful for primary isolation of the agent, the hamster could be used for propagation of organisms recovered primarily in the cotton rat. Both animals developed pneumonitis in consequence of infection. Immune responses of patients and experimental hosts were demonstrated by the neutralization of sputum infectivity for animals following incubation of the inoculum with convalescent sera (2).


Syrian Hamster Mycoplasma Pneumoniae Sephadex G200 Column Intranasal Inoculation Convalescent Seron 
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Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Wallace A. ClydeJr.
    • 1
  • Gerald W. Fernald
    • 1
  1. 1.Departments of Pediatrics and Bacteriology and ImmunologyUniversity of North Carolina School of MedicineChapel HillUSA

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