Immune Response of the Hamster to Experimental Mycoplasma Pneumoniae Disease
The Syrian hamster (Mesocricetus auratus) first was used for experimental Mycoplasma pneumoniae infections soon after the introduction of this species as a laboratory animal in the United States. Isolation of an infectious agent from patients with atypical pneumonia by intranasal inoculation of cotton rats (Sigmodon hispidus) with sputum samples was reported in 1942. Although unsuccessful for primary isolation of the agent, the hamster could be used for propagation of organisms recovered primarily in the cotton rat. Both animals developed pneumonitis in consequence of infection. Immune responses of patients and experimental hosts were demonstrated by the neutralization of sputum infectivity for animals following incubation of the inoculum with convalescent sera (2).
KeywordsSyrian Hamster Mycoplasma Pneumoniae Sephadex G200 Column Intranasal Inoculation Convalescent Seron
Unable to display preview. Download preview PDF.
- 4.Clyde, W.A., Jr. Proc Soc Exp Biol Med 107 (1961) 716.Google Scholar
- 9.Kenny, G.E.; Grayston, J.T. J Immunol 95 (1965) 19.Google Scholar
- 11.Fernald, G.W. et al. J Immunol 98 (1972) 1028.Google Scholar
- 17.Brunner, H. et al. Infect Immun 9 (1973) 612.Google Scholar
- 18.Fernald, G.W. In: The Secretary Immunologic System. U.S. Dept. of Health, Education and Welfare, Washington, D.C. (1969) 215.Google Scholar
- 19.Fernald, G.W.; Clyde, W.A., Jr. In: Immunologie and Infectious Reactions in the Lung, ed. Kirkpatrick and Reynolds. Dekker, New York (1976) 101.Google Scholar