Anti-Viral Cytotoxic Lymphocyte Response in Hamsters with Parainfluenza Virus Type 3 Infection
The Syrian hamster is a useful model for experimental studies of immunity to agents causing acute respiratory disease because it is susceptible to several significant human pathogens, including influenza A viruses, parainfluenza virus 3 (P3), and Mycoplasma pneumoniae. The importance of cell-mediated immune mechanisms in respiratory virus infections remains an unresolved issue. A developing body of clinical experience suggests that cellular immune competence is required for resolution of respiratory syncytial virus, influenza A, and parainfluenza 3 infections in man. Prolonged infections with these agents have been identified in children with inborn and acquired disorders of cellular immunity (1). Recent studies of influenza A infection in mice suggest that a local cytotoxic T lymphocyte response may contribute to termination of intrapulmonary virus replication (2). Determination of the relative and quantitative significance of the cellular response, however, has proven difficult. Futhermore, since most studies of influenzal immunity employ “mouse-adapted” alveolar-tropic strains of virus, conclusions reached from these studies may not be directly applicable to other viral agents that infect the lung. We have examined the pulmonary cellular immune response of hamsters to P3 infection in order to develop a better understanding of immunity to viral infection of intrapulmonary airways (3).
KeywordsRespiratory Syncytial Virus Syrian Hamster Mycoplasma Pneumoniae Sendai Virus Influenzal Immunity
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