A Relationship between SV40-transformed Cell Susceptibility to Macrophage Killing and Tumor Induction in Rodents
Simian virus 40 (SV40) is a papovavirus that induces tumors in golden Syrian hamsters and transforms cells from many species in tissue culture (1). The ability of SV40-transformed hamster cells, but not cells from other species transformed by SV40, to induce tumors in the host (2) implies that in transformation of hamster cells, SV40 may induce a species-specific change that renders the neoplastic cells resistant to rejection by the host. Previous studies by the authors suggested that LSH hamster cells transformed by adenovirus 2 (Ad2, a human virus not oncogenic in newborn hamsters) (3,4) are susceptible to rejection by a thymus-dependent, cell-mediated host response (5,6,7). The resistance of SV40-transformed LSH cells to rejection by syngeneic animals and the recent observation that SV40-transformed LSH cells induce tumors in histoincompatible CB hamsters almost as efficiently as in syngeneic animals (8) support the hypothesis that SV40 alters the efficiency with which the hamster cells it transforms are recognized or destroyed by the host.
KeywordsTarget Cell Golden Syrian Hamster Peritoneal Exudate Cell Tumoricidal Effect Hamster Cell Line
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