Natural Cytotoxicity by Hamster Lymphoid Cells for Virus-Infected and Transformed Cells
Cell-mediated immunity is a significant aspect of the host response to herpes simplex virus (HSV) infection. Several investigators have shown that adoptive transfer of immune T lymphocytes will protect mice against virus challenge (1,2,3). More recently, in vitro studies have shown that draining lymph node (4,5) or spleen cells (6) from virus-sensitized hosts were specifically cytotoxic for HSV-infected cells. Substantial levels of lysis usually were not seen, however, unless the effector cells, identified as T lymphocytes (6,7) first had experienced some form of experimental manipulation such as incubation in vitro for a number of days.
KeywordsHerpes Simplex Virus Herpes Simplex Virus Type Peripheral Blood Lymphocyte Natural Cytotoxicity Decyl Sulfate
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