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Hemolytic Complement and Its Components in Syrian Hamsters: A Study of Five Strains Uninfected and Infected with Brugia Pahangi

  • Ota Barta
  • Priscilla P. Oyekan
  • John B. Malone
  • Thomas R. Klei
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 134)

Abstract

Few studies have been done on the hamster complement system (C). Our previous study showed that sensitized sheep erythrocytes were the best target cells for the hemolytic action of hamster C. The reaction proceeded best at pH 7.3, at an ionic strength of 0.147 and in the presence of lmM Mg2+ and 0.3mM Ca2+ (1). All nine C components were tested in hamsters by use of commercially prepared cellular intermediates of sensitized sheep erythrocytes and guinea pig (C1, C8 and C9) and human C components (C2, C3, C4, C5–7) (1). Successful testing of hamster total C, C1, C4, and C2 has been reported (2). Other workers (3) reporting on C6 deficiency in unspecified strains of Syrian hamsters found a correlation of this deficiency with a high incidence of proliferative enteritis.

Keywords

Syrian Hamster Uninfected Animal CH50 Unit Cellular Intermediate Sensitize Sheep Erythrocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Barta, O.; Klei, T.R. Dev Comp Immunol 2 (1978) 519.PubMedCrossRefGoogle Scholar
  2. 2.
    Hook, W.A. et al. J Immunol 105 (1970) 268.PubMedGoogle Scholar
  3. 3.
    Yang, S.Y. et al. Fed Proc 33 (1974) 795 (Abstr.).Google Scholar
  4. 4.
    Mayer, M.M. In: Experimental Immuno chemistry, ed. Kabat and Mayer, 2nd ed. Charles C. Thomas, Springfield, Ill. (1961) 149.Google Scholar
  5. 5.
    Malone, J.B.; Thompson, P.E. Exp Parasitol 38 (1975) 279.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1981

Authors and Affiliations

  • Ota Barta
    • 1
  • Priscilla P. Oyekan
    • 1
  • John B. Malone
    • 1
  • Thomas R. Klei
    • 1
  1. 1.Department of Veterinary Microbiology and Parasitology School of Veterinary MedicineLouisiana State UniversityBaton RougeUSA

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