Hemolytic Complement and Its Components in Syrian Hamsters: A Study of Five Strains Uninfected and Infected with Brugia Pahangi
Few studies have been done on the hamster complement system (C). Our previous study showed that sensitized sheep erythrocytes were the best target cells for the hemolytic action of hamster C. The reaction proceeded best at pH 7.3, at an ionic strength of 0.147 and in the presence of lmM Mg2+ and 0.3mM Ca2+ (1). All nine C components were tested in hamsters by use of commercially prepared cellular intermediates of sensitized sheep erythrocytes and guinea pig (C1, C8 and C9) and human C components (C2, C3, C4, C5–7) (1). Successful testing of hamster total C, C1, C4, and C2 has been reported (2). Other workers (3) reporting on C6 deficiency in unspecified strains of Syrian hamsters found a correlation of this deficiency with a high incidence of proliferative enteritis.
KeywordsSyrian Hamster Uninfected Animal CH50 Unit Cellular Intermediate Sensitize Sheep Erythrocyte
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