Fractionation of Tobacco Smoke Condensate for Chemical Composition Studies

  • William J. Chamberlain
  • R. L. Stedman


The evolution of the scheme presently used at the Russell Research Center for the fractionation of smoke condensate will be outlined. This work was carried out for the most part at the Eastern Marketing and Nutrition Laboratory under the direction of Dr. R. L. Stedman. The fractions obtained from the separation procedures are used in both chemical and biological investigations. The results obtained in the biological studies on these fractions will be discussed in another paper by Dr. Bock. Some fractions which were found to be active will be pointed out as a justification for studying the chemistry of the particular fraction and developing further fractionation schemes. This paper is also not intended to be a complete discussion of chemical composition but rather a means of isolating various fractions for chemical studies. Compounds identified in our laboratories will be presented in order to give a general idea of the composition of various fractions.


Silicic Acid Neutral Fraction Silicic Acid Column Cigarette Smoke Condensate Dimethyl Phenyl 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    R. L. Stedman, R. C. Benedict, M. Dymicky and D. B. Bailey. Beitr. Tabakforsch. 5, 97–103 (1969).Google Scholar
  2. 2.
    Ernest L. Wynder and Dietrich Hoffmann, “Tobacco and Tobacco Smoke” Academic Press, New York (1967).Google Scholar
  3. 3.
    I. Schmeltz, C. J. Dooley, R. L. Stedman and W. J. Chamberlain. Phytochem. 6, 33–38 (1967).CrossRefGoogle Scholar
  4. 4.
    R. L. Miller, L. Lakritz, C. J. Dooley and R. L. Stedman. Tob. Sci. 11, 35–36 (1967).Google Scholar
  5. 5.
    A. P. Swain, J. E. Cooper, and R. L. Stedman. Cancer Research 29, 579 (1969).Google Scholar
  6. 6.
    Fred G. Bock, A. P. Swain and R. L. Stedman. Cancer Research 29, 584 (1969).Google Scholar
  7. 7.
    R. L. Stedman, R. L. Miller, L. Lakritz and W. J. Chamberlain. Chem. and Ind. 394 (1968).Google Scholar
  8. 8.
    R. L. Miller, W. J. Chamberlain and R. L. Stedman. Tob. Sci. 13, 21 (1969).Google Scholar
  9. 9.
    R. L. Miller, and R. L. Stedman, Phytochem. 10, 1135 (1971).CrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1972

Authors and Affiliations

  • William J. Chamberlain
    • 1
  • R. L. Stedman
    • 2
  1. 1.Richard B. Russell Agricultural Research CenterARS, USDAAthensUSA
  2. 2.Eastern Marketing and Nutrition LaboratoryARS, USDAPhiladelphiaUSA

Personalised recommendations