The Structure of the Canine Coronavirus
During a survey of canine sera in 1970, Norman and his associates detected antibodies to porcine transmissible gastroenteritis (TGEV). Since many of the dogs had never been in contact with pigs it was unlikely that this reflected infection with the porcine virus, suggesting the existence of a canine virus that was serologically related to TGEV. Further evidence to support this was provided by the study by Cartwright and Lucas (1972) of an outbreak of gastroenteritis in a kennel of 40 dogs in which rising antibody titres to TGEV were found. Although neither of these studies could find evidence of transmission of TGEV from pigs to dogs, this possibility could not be discounted since Haelterman (1962) had clearly demonstrated that dogs and foxes could be infected with the porcine virus. Dogs that were experimentally infected with TGEV showed no clinical signs but the virus could be reisolated from faeces and TGEV-neutralizing antibodies were produced in the serum.
KeywordsMajor Polypeptide Structural Polypeptide Transmissible Gastroenteritis Virus Feline Infectious Peritonitis Virus Subviral Particle
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