The Structure of the Canine Coronavirus

  • David J. Garwes
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)


During a survey of canine sera in 1970, Norman and his associates detected antibodies to porcine transmissible gastroenteritis (TGEV). Since many of the dogs had never been in contact with pigs it was unlikely that this reflected infection with the porcine virus, suggesting the existence of a canine virus that was serologically related to TGEV. Further evidence to support this was provided by the study by Cartwright and Lucas (1972) of an outbreak of gastroenteritis in a kennel of 40 dogs in which rising antibody titres to TGEV were found. Although neither of these studies could find evidence of transmission of TGEV from pigs to dogs, this possibility could not be discounted since Haelterman (1962) had clearly demonstrated that dogs and foxes could be infected with the porcine virus. Dogs that were experimentally infected with TGEV showed no clinical signs but the virus could be reisolated from faeces and TGEV-neutralizing antibodies were produced in the serum.


Major Polypeptide Structural Polypeptide Transmissible Gastroenteritis Virus Feline Infectious Peritonitis Virus Subviral Particle 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Binn, L.N., Lazar, E.C., Keenan, K.P., Huxsoll, D.L., Marchwicki, R.H. and Strano, A.J., 1975, Recovery and characterization of a coronavirus from military dogs with diarrhoea, Proc. 78th Meeting U.S. Anim. Hlth. Assoc., 359.Google Scholar
  2. Cartwright, S.F. and Lucas, M.H., 1972, Vomiting and diarrhoea in dogs, Vet. Rec, 91: 571.PubMedCrossRefGoogle Scholar
  3. Garwes, D.J., 1980, Structure and physicochemical properties of coronaviruses, in: “Viral Enteritis in Humans and Animals”, I.N.S.E.R.M., Grignon, France.Google Scholar
  4. Garwes, D.J. and Pocock, D.H., 1975, The polypeptide structure of transmissible gastroenteritis virus, J. gen. Virol., 29: 25.PubMedCrossRefGoogle Scholar
  5. Garwes, D.J., Pocock, D.H. and Pike, B.V., 1976, Isolation of subviral components from transmissible gastroenteritis virus, J. gen. Virol., 32: 283.PubMedCrossRefGoogle Scholar
  6. Garwes, D.J. and Reynolds, D.J., 1980, The polypeptide structure of canine coronavirus and its relationship to porcine transmissible gastroenteritis virus, J. gen. Virol., in the press.Google Scholar
  7. Haelterman, E.O., 1962, Epidemiological studies of transmissible gastroenteritis of swine, Proc. 66th Ann. Meeting U.S. Livestock Sanit. Assoc., 305.Google Scholar
  8. Norman, J.O., McClurkin, A.W. and Stark, S.L., 1970, Transmissible gastroenteritis (TGE) of swine: Canine serum antibodies against an associated virus, Can. J. Comp. Med., 34: 115.PubMedGoogle Scholar
  9. Reynolds, D.J. and Garwes, D.J., 1979, Virus isolation and serum antibody responses after infection of cats with transmissible gastroenteritis virus, Arch. Virol., 60: 161.PubMedCrossRefGoogle Scholar
  10. Reynolds, D.J., Garwes, D.J. and Gaskell, C.J., 1977, Detection of transmissible gastroenteritis virus neutralising antibody in cats, Arch. Virol., 55: 77.PubMedCrossRefGoogle Scholar
  11. Reynolds, D.J., Garwes, D.J. and Lucey, S., 1980, Differentiation of canine coronavirus and porcine transmissible gastroenteritis virus with canine, porcine and feline sera, Vet. Microbiol., in the press.Google Scholar
  12. Sturman, L.S., 1977, Characterization of a coronavirus. 1. Structural proteins: Effects of preparative conditions on the migration of protein in polyacrylamide gels, Virology, 77: 637.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • David J. Garwes
    • 1
  1. 1.Institute for Research on Animal Diseases ComptonAgricultural Research CouncilNr. NewburyUK

Personalised recommendations