Macrophages and Resistance to JHM Virus CNS Infection

  • Stephen A. Stohlman
  • Jeffrey A. Frelinger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)


The macrophage is an important cell in determining the outcome of viral infections, especially those due to herpes and mouse hepatitis viruses (Morgensen, 1979). Mouse hepatitis virus (MHV), is a member of the coronavirus group which are positive stranded RNA viruses (Lai and Stohlman, 1978) and produce a wide spectrum of diseases in their natural hosts (Mclntosch, 1973). The principle organs attacked by MHV during infection are the liver and the central nervous system (CNS). Bang and co-workers have demonstrated a genetic basis for the resistance of mice to fatal hepatitis caused by MHV and that in vitro macrophages from resistant animals exhibit resistance parallel to that determined in vivo (Bang, 1978). They have shown that MHV can only replicate in vitro in macrophages from susceptible animals. This type of resistance appears to be analogous to the intrinsic resistance described for herpes viruses (Johnson, 1964). Intrinsic resistance to viral replication limits virus dissemination thereby affording protection to the target organ and the host. Recently, we have demonstrated the ability of passively transferred macrophages to confer resistance to the JHM strain of MHV (MHV-JHM) induced acute CNS disease (Stohlman et al, 1980). However, macrophages from both susceptible and resistant animals exhibited intrinsic resistance to MHV-JHM replication.


Antiviral Activity Intrinsic Resistance Peritoneal Exudate Nonspecific Esterase Peritoneal Exudate Cell 
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Stephen A. Stohlman
    • 1
  • Jeffrey A. Frelinger
    • 1
  1. 1.University of Southern California School of MedicineLos AngelesUSA

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