Host and Virus Factors Associated with CNS Cellular Tropism Leading to Encephalomyelitis or Demyelination Induced by the JHM Strain of Mouse Hepatitis Virus

  • Robert L. Knobler
  • Martin V. Haspel
  • Monique Dubois-Dalcq
  • Peter W. Lampert
  • Michael B. A. Oldstone
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)

Abstract

Infection of mice with the neurotropic JHM strain (type 4) of mouse hepatitis virus (MHV), produces a spectrum of disease ranging from acute fatal encephalomyelitis (E+) to demyelination (D+) (Bailey et al., 1949; Haspel et al., 1978; Lampert et al., 1973; Weiner, 1973). The pattern of disease which prevails is affected by such factors as the age of the animal, the dose of virus administered, the route of infection (Weiner, 1973), the genetic strain of the mouse (Stohlman and Frelinger, 1978), and the nature of the virus (Haspel et al., 1978).

Keywords

Hepatitis Paraformaldehyde Glutaraldehyde Tetanus Encephalomyelitis 

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References

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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Robert L. Knobler
    • 1
    • 4
  • Martin V. Haspel
    • 2
  • Monique Dubois-Dalcq
    • 3
  • Peter W. Lampert
    • 4
  • Michael B. A. Oldstone
    • 1
  1. 1.Department of ImmunopathologyScripps Clinic and Research FoundationLa JollaUSA
  2. 2.Laboratory of Oral MedicineNational Institute of Dental ResearchBethesdaUSA
  3. 3.NINCDSInfectious Disease BranchBethesdaUSA
  4. 4.Department of PathologyUCSD College of MedicineLa JollaUSA

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