Host and Virus Factors Associated with CNS Cellular Tropism Leading to Encephalomyelitis or Demyelination Induced by the JHM Strain of Mouse Hepatitis Virus
Infection of mice with the neurotropic JHM strain (type 4) of mouse hepatitis virus (MHV), produces a spectrum of disease ranging from acute fatal encephalomyelitis (E+) to demyelination (D+) (Bailey et al., 1949; Haspel et al., 1978; Lampert et al., 1973; Weiner, 1973). The pattern of disease which prevails is affected by such factors as the age of the animal, the dose of virus administered, the route of infection (Weiner, 1973), the genetic strain of the mouse (Stohlman and Frelinger, 1978), and the nature of the virus (Haspel et al., 1978).
KeywordsHepatitis Paraformaldehyde Glutaraldehyde Tetanus Encephalomyelitis
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