Advertisement

JHM Infections in Rats as a Model for Acute and Subacute Demyelinating Disease

  • Helmut Wege
  • Makoto Koga
  • Hanna Wege
  • Volker ter Meulen
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)

Summary

An animal model with different central nervous system (CNS) disease processes associated with demyeli-nation is described which provides a basis to analyse the pathogenetic mechanisms leading to these disorders. Intracerebral infection of rats with the murine corona-virus strain JHM can result in an acute encephalomyelitis with a short incubation period or in subacute to chronic encephalomyelitis occurring after prolonged incubation. The most prominent finding of the latter two diseases consists of typical demyelinated lesions distributed in selected areas of the CNS. The induction of high rates of animals with demyelination depends both on properties of the virus used for infection and host factors such as age and immune status. A high number of rats with demyelination was obtained by intracerebral inoculation of temperature sensitive mutants into suckling rats with maternal JHM antibodies.

Keywords

DEMYELINATING Disease Mouse Hepatitis Virus Intracerebral Inoculation Prolonged Incubation Period Virus Induce Demyelination 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bailey, O.T., Pappenheimer, A.M., Sargent Cheever, F. and Daniels, J.B. (1949). A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin: II. Pathology. Journal of Experimental Medicine 90, 195–212.CrossRefGoogle Scholar
  2. 2.
    Cheever, F.S., Daniels, J.B., Pappenheimer, A.M. and Bailey, O.T. (1949). A murine virus (JHM) causing disseminated encephalomyelitis with extensive destruction of myelin: I. Isolation and biological properties of the virus. Journal of Experimental Medicine 90, 181–194.PubMedCrossRefGoogle Scholar
  3. 3.
    Haspel, V.M., Lampert, P.W. and Oldstone, M.B.A. (1978). Temperature-sensitive mutants of mouse hepatitis virus produce a high incidence of demyeli-nation. Proceedings of the national Academy of Science, USA, 75 4033–4036.CrossRefGoogle Scholar
  4. 4.
    Herndon, R.M., Griffin, D.E., McCormick, U. and Weiner, L.P. (1975). Mouse hepatitis virus induced recurrent demyelination. Archives of Neurology 32, 32–35.PubMedCrossRefGoogle Scholar
  5. 5.
    Lampert, P.W., Sims, J.K. and Kniazeff, A.J. (1973). Mechanism of demyelination in JHM virus encephalomyelitis. Electron microscopic studies. Acta Neuropathologica 24, 76–85.PubMedCrossRefGoogle Scholar
  6. 6.
    ter Meulen, V. and Hall, W.W. (1978). Slow virus infections of the nervous systems. Journal of General Virology 41, 1–25.PubMedCrossRefGoogle Scholar
  7. 7.
    Nagashima, K., Wege, H. and ter Meulen, V. (1978). Early and late CNS-effects of coronavirus infection in rats. Advances of experimental Medicine and Biology 100, 395–409.CrossRefGoogle Scholar
  8. 8.
    Nagashima, K., Wege, H., Meyermann, R. and ter Meulen, V. (1978). Corona virus induced subacute demyelinating encephalomyelitis in rats. A morphological analysis. Acta Neuropathologica 44, 63–70.PubMedCrossRefGoogle Scholar
  9. 9.
    Nagashima, K., Wege, H., Meyermann, R. and ter Meulen, V. (1979). Demyelinating encephalomyelitis induced by a long-term corona virus infection in rats. Acta Neuropathologica 45, 205–213PubMedCrossRefGoogle Scholar
  10. 10.
    Fujinami, R.S. and Oldstone, M.B.A. (1979). Antiviral antibody acting on the plasma membrane allows measles virus expression inside the cell. Nature 279, 529–530.PubMedCrossRefGoogle Scholar
  11. 11.
    Sorensen, O., Percy, D. and Dales, S. (1980). In vivo and in vitro models of demyelinating diseases. III. JHM virus infection of rats. Archives of Neurology 37, 478–484.PubMedCrossRefGoogle Scholar
  12. 12.
    Wege, H., Stephenson, J.R., Koga, M., Wege, Hanna and ter Meulen, V. (1981). Genetic variation of neu-rotropic and non neurotropic murine coronaviruses. Journal of General Virology, in press.Google Scholar
  13. 13.
    Weiner, L.P. (1973). Pathogenesis of demyelination included by a mouse hepatitis virus (JHM virus). Archives of Neurology 28, 293–303.CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • Helmut Wege
    • 1
  • Makoto Koga
    • 1
  • Hanna Wege
    • 1
  • Volker ter Meulen
    • 1
  1. 1.Institute for Virology and ImmunobiologyUniversity of WürzburgWürzburgFederal Republic of Germany

Personalised recommendations