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Coronavirus Antibodies in Patients with Multiple Sclerosis

  • P. O. Leinikki
  • Kathryn V. Holmes
  • Isabel Shekarchi
  • M. Iivanainen
  • D. Madden
  • J. L. Sever
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)

Abstract

Several strains of murine coronavirus are able to induce a demyelinative disease in laboratory animals. The disease is characterized by a chronic course with relapses after the initial phase of acute encephalitis (Herdon et al., 1975; Holmes et al., 1980). Recently a coronavirus has also been implicated in human demyelin-ative disease, multiple sclerosis (Burks et al., 1980). In order to determine whether a coronavirus etiology for MS could be demonstrated in analogy to the role of measles virus in SSPE, we have studied the occurrence of coronavirus antibodies in two collections of clinical material.

Keywords

Multiple Sclerosis Multiple Sclerosis Patient Optic Neuritis Measle Virus Acute Encephalitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Burks, J.S., DeVald, B.L., Jankovsky, L.D., and Gerdes, J.C., 1980, Two coronaviruses isolated from central nervous system tissue of two multiple sclerosis patients, Science, 209: 933–934.PubMedCrossRefGoogle Scholar
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Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • P. O. Leinikki
    • 1
    • 2
    • 3
  • Kathryn V. Holmes
    • 1
    • 2
    • 3
  • Isabel Shekarchi
    • 1
    • 2
    • 3
  • M. Iivanainen
    • 1
    • 2
    • 3
  • D. Madden
    • 1
    • 2
    • 3
  • J. L. Sever
    • 1
    • 2
    • 3
  1. 1.Institute of Biomedical SciencesUniversity of TampereFinland
  2. 2.Infections Diseases Branch, NINCDS, NIHBethesdaUSA
  3. 3.Department of PathologyUniform Services University of the Health SciencesBethesdaUSA

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