Coronavirus Antibodies in Patients with Multiple Sclerosis
Several strains of murine coronavirus are able to induce a demyelinative disease in laboratory animals. The disease is characterized by a chronic course with relapses after the initial phase of acute encephalitis (Herdon et al., 1975; Holmes et al., 1980). Recently a coronavirus has also been implicated in human demyelin-ative disease, multiple sclerosis (Burks et al., 1980). In order to determine whether a coronavirus etiology for MS could be demonstrated in analogy to the role of measles virus in SSPE, we have studied the occurrence of coronavirus antibodies in two collections of clinical material.
KeywordsMultiple Sclerosis Multiple Sclerosis Patient Optic Neuritis Measle Virus Acute Encephalitis
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- Holmes, K., Leinikki, P., Shekarchi, I., and Sever, J.L., 1980, A chronic neurological disease induced by murine coronavirus strain A 59. In preparation.Google Scholar
- Leinikki, P., Shekarchi, I., Iivanainen, M., Taskinen, E., Holmes, K., Madden, D., and Sever, J., 1980, Virus antibodies in the cerebrospinal fluid in multiple sclerosis by using ELISA. Neurology, submitted.Google Scholar
- Madden, D., Wallen, W., Houff, S., Shekarchi, I., Leinikki, P., Castellano, G., Holmes, K., and Sever, J., Humoral and cellular immune responses of multiple sclerosis patients.Google Scholar