Evolution of a Coronavirus during Persistent Infection inVitro
Coronaviruses usually infect epithelial cells of the gastro-enteric or respiratory tracts. They frequently cause local infections which may be fatal in young animals, but which are usually mild or asymptomatic in adults. In vitro, coronaviruses may induce virulent, cytolytic and cell fusing effects in some host cells but cause a moderate, persistent infection in other cell types. Thus the host or the host cell appears to be of critical importance in determining the outcome of coronavirus infection. This report will focus on the role of the host cell in coronavirus replication and on the mutually dependent changes induced in the host cell and the virus during the establishment of a persistent infection in vitro.
KeywordsRough Endoplasmic Reticulum Persistent Infection Infectious Bronchitis Virus Wild Type Virus Mouse Hepatitis Virus
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