Comparison of the RNAs of Murine and Human Coronaviruses
Coronaviruses cause acute and/or persistent disease in many species of animals. One factor that determines target organ and lethality of coronavirus infection is the strain of virus (McIntosh, 1972; Robb et al., 1980). For example most strains of mouse hepatitis virus (MHV), such as A59 and MHV3, were isolated from the livers of infected mice and are primarily hepatotropic (McIntosh, 1974). In contrast the JHM strain of MHV is primarily neurotropic (McIntosh 1974: Bailey et al., 1949). Most MHV strains are closely related serologically (McIntosh, 1974).
KeywordsMolecular Hybridization Human Coronavirus Avian Sarcoma Virus Human CORONAVIRUSES Intracellular RNAs
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