The Avian Coronavirus Multiplication Strategy

  • David Stern
  • Loyd Burgess
  • Steve Linesch
  • Ian Kennedy
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 142)


Infectious bronchitis virus (IBV), the prototype of the coronavirus family, possesses a single-stranded polyadenylated RNA genome. This genome consists of a single polynucleotide chain with an estimated molecular weight of between 6 and 9 × 106,1,2,3,4. Since the genome is infectious, i.e., it is of positive polarity,5 it must encode both the structural proteins of the virus particle and non-structural polypeptides some or all of which function in the infected cell to replicate the virus genetic material and to transcribe viral mRNA.


Apparent Molecular Weight Infectious Bronchitis Virus Semliki Forest Virus Subgenomic RNAs Structural Polypeptide 


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  1. 1.
    B. Lomniczi and I. Kennedy, Genome of infectious bronchitis virus, J. Virol. 24: 99 (1977).PubMedGoogle Scholar
  2. 2.
    M.R. MacNaughton and M.H. Madge, The characterization of the virion RNA of avian infectious bronchitis virus, FEBS Letters 77: 311 (1977).PubMedCrossRefGoogle Scholar
  3. 3.
    J.A. Robb and C.W. Bond, Coronaviridae, in: “Comprehensive Virology,” H. Frankel-Conrat and R.R. Wagner, eds., Plenum Press, New York.Google Scholar
  4. 4.
    G. Schochetman, R.H. Stevens and R.W. Simpson, Presence of infectious polyadenylated RNA in the coronavirus avian bronchitis virus, Virology 77: 772 (1977).PubMedCrossRefGoogle Scholar
  5. 5.
    B. Lomniczi, Biological properties of avian coronavirus RNA, J. Gen. Virol. 36: 531 (1977).PubMedCrossRefGoogle Scholar
  6. 6.
    D.F. Stern and S.I.T. Kennedy, Coronavirus multiplication strategy I. Identification and characterization of virusspecified RNA, J. Virol. 34: 665 (1980).PubMedGoogle Scholar
  7. 7.
    D.F. Stern and S.I.T. Kennedy, Coronavirus multiplication strategy II. Mapping the IBV intracellular RNA species to the genome, J. Virol., in press.Google Scholar
  8. 8.
    L. Burgess, D.F. Stern, S. Linesch, B. Sefton and S.I.T. Kennedy, The coronavirus multiplication strategy. III. Synthesis of the virion structural proteins, in preparation.Google Scholar
  9. 9.
    L.S. Sturman, K.V. Holmes and J. Behnke, Isolation of coronavirus envelope glycoproteins and interaction with the viral nucleocapsid, J. Virol. 33: 449 (1980).PubMedGoogle Scholar
  10. 10.
    M.J. Morser, S.I.T. Kennedy and D.C. Burke, Virus-specified polypeptides in cells infected with Semliki Forest virus, J. Gen. Virol. 21: 19 (1973).PubMedCrossRefGoogle Scholar
  11. 11.
    S.G. Siddell, H. Wege, A. Barthel and V. terMeulen, Coronavirus JHM: cell-free synthesis of structural protein p 60, J. Virol. 33: 10 (1980).PubMedGoogle Scholar
  12. 12.
    M.F. Jacobson and D. Baltimore, Polypeptide cleavages in the formation of poliovirus proteins, Proc. Natl. Acad. Sci. USA 61: 77 (1968).PubMedCrossRefGoogle Scholar
  13. 13.
    S.I.T. Kennedy, Sequence relationships between the genome and the intraceliular RNA species of standard and defectiveinterfering Semiiki Forest virus, J. Mol. Biol. 108: 491 (1976).PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1981

Authors and Affiliations

  • David Stern
    • 1
    • 2
  • Loyd Burgess
    • 1
    • 2
  • Steve Linesch
    • 1
  • Ian Kennedy
    • 1
  1. 1.Department of BiologyUniversity of California, San DiegoLa JollaUSA
  2. 2.The Salk InstituteLa JollaUSA

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