The Structure and Behavior of Coronavirus A59 Glycoproteins
Coronavirus A59 contains three structural proteins. The location of these proteins in relation to the viral envelope and RNA are illustrated in the model shown in Figure 1. A nucleocapsid protein, N, (mw ≃ 50k) forms the nucleocapsid together with the RNA genome. Surrounding the nucleocapsid is a lipoprotein membrane which contains the envelope glycoproteins El (mw ≃ 23k) and E2 (mw ≃180k and 90k). El is an integral membrane protein, the bulk of which lies within the viral membrane and probably spans the lipid bilayer. E2 is a peripheral glycoprotein which forms the characteristic peplomers that are associated with this virion.
KeywordsElectrophoretic Mobility Viral Envelope Envelope Glycoprotein Nucleocapsid Protein Tris Maleate
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