Quantitative Measurement of Atherosclerosis by Angiography: Implications for Primary Prevention

  • Dieter M. Kramsch
  • Robert H. Selzer
  • David H. Blankenhorn
Part of the Nato ASI Series book series (NSSA, volume 219)


There are two ways to test therapy for atherosclerosis in man: trials which measure cardiovascular death rates and trials that measure the rate of change in atherosclerotic lesions. Mortality-based trials require large study groups and relatively long periods of observation. Lesion tracking trials require fewer study subjects and shorter periods of observation, but are dependent on valid reliable assessment of lesion changes. To date, coronary angiography has been the major endpoint measure used in lesion trials. This review covers factors which influence the performance of angiography.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Dieter M. Kramsch
    • 1
  • Robert H. Selzer
    • 2
  • David H. Blankenhorn
    • 1
  1. 1.University of Southern California School of MedicineLos AngelesUSA
  2. 2.Jet Propulsion LaboratoryPasadenaUSA

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