Effect of Native and Oxidized LDL on Vascular Tone
The atherogenic properties of low density lipoproteins (LDL) are well established, and recent evidence suggests that oxidation of LDL is an important step in atherogenesis (1). However, it remains controversial whether lipoproteins directly affect arterial endothelial function or smooth muscle tone. Several studies showed impairment of endothelium-mediated vasodilation in hypercholesterolemia in animals and humans (2, 3), and an arterial hyperresponsiveness to different vasoconstrictors in hypercholesterolemic animals (2, 4, 5). In in vitro investigations, it was found that both Human Native (n) LDL and Oxidized (ox) LDL can be cytotoxic to endothelial cells (6), and recently it was proposed that high concentrations of LDL inhibit endothelium-derived relaxing factor (EDRF) formation via the endothelial LDL-receptor (7).
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