Membrane Physiologic Aspects of the Adjustment of Peripheral Vascular Tone
A variety of local or systemic influences regulate peripheral organ perfusion, e.g. K+ ions, pH value, noradrenaline, prostacyclin, endothelial factors (1). With the multiplicity of effectors, and since several can be changed at the same time, the question of mechanism arises. To refer to Sherrington (2), it is important to find the “final common pathway” of their integration, even in the vascular smooth muscle cell. Electrophysiology opens up one approach to this problem. Nevertheless, biochemical processes in the cell membrane and in the cell interior have a part to play, particularly when the transmembrane passage of ions is modulated by the known intracellular second messengers like Ca2+, cAMP, cGMP, GTP-binding proteins, protein kinase C and ATP (3). This study deals mainly with the regulation of smooth muscle tone by the membrane potential with voltage-gated channels predominating.
KeywordsPermeability Titration Electrophoresis CaCl Prostaglandin
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- 1.G. Siegel, Membranphysiologische Grundlagen der peripheren Gefäßregulation, Phvsiol. akt. 1:31 (1986).Google Scholar
- 2.C. S. Sherrington, Correlation of reflexes and the principle of the common path, Brit. Ass. Rep. 728 (1904).Google Scholar
- 4.G. Siegel and W. Schneider, Anions, cations, membrane potential, and relaxation, in: “Vasodilatation,” P. M. Vanhoutte and I. Leusen, eds. Raven Press, New York (1981).Google Scholar
- 6.G. Siegel, M. Bostanjoglo, M. Thiel, A. Adler, A. Carl, G. Stock, and J. Grote, Membranphysiologische Mechanismen der Vasodilatation, in: “Frühveränderungen bei der Atherogenese,” E. Betz, ed., W. Zuckschwerdt Verlag, München (1987).Google Scholar
- 8.G. Siegel and J. Grote, Po2-induced changes of membrane potential and tension in vascular smooth musculature, in: “Oxygen Sensing in Tissues,” H. Acker, ed., Springer-Verlag, Berlin (1988).Google Scholar
- 9.G. Siegel, F. Schnalke, G. Stock, and J. Grote, Prostacyclin, endothelium-derived relaxing factor and vasodilatation. Adv. Prostaglandin Thromboxane Leukotriene Res. 19:267 (1989).Google Scholar
- 12.T. Teorell, Membrane electrophoresis in relation to bioelectrical polarization effects. Arch. Sci. Physiol. 3:205 (1949).Google Scholar
- 13.A. L. Hodgkin, A. F. Huxley, and B. Katz, Measurement of current-voltage relations in the membrane of the giant axon of Loligo. J. Physiol. (Lond.) 116:424 (1952).Google Scholar
- 15.G. Siegel, The effect of external pH changes on Na2+ and K2+permeabilities in the smooth muscle fibre membrane of canine cerebral vessels, J. Physiol. (Lond.) 329:56P (1982).Google Scholar
- 16.G. Siegel, J. Mironneau, F. Schnalke, G. Schröder, B.-G. Schulz, and J. Grote, Vasodilatation evoked by K2+ channel opening, Prog. Clin. Biol. Res. 327:299 (1990).Google Scholar
- 18.G. Siegel, A. Walter, A. W. H. Jans, and R. Kinne, Binding of mono- and divalent cations to different components of the extracellular matrix, Abhandl. Rhein.-Westf. Akad. Wissensch. 82:155 (1989).Google Scholar