Constriction and Dilatation in Atherosclerotic and Hypertensive Arteries

  • Donald D. Heistad
  • J. Antonio G. Lopez
  • Frank M. Faraci
  • Mark L. Armstrong
Part of the Nato ASI Series book series (NSSA, volume 219)


We will emphasize three points that pertain to approaches to quantification of changes in atherosclerotic lesions.


Atherosclerotic Lesion Vascular Reactivity Vascular Response Chronic Hypertension Vasodilator Response 
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  1. 1.
    R.L. Jayakody, M.P.J. Senaratne, A.B.R. Thomson, C.T. Kappagoda, Cholesterol feeding impairs endothelium-dependent relaxation of rabbit aorta, Can. J. Physiol. Pharmacol 63:1206–1209 (1985).PubMedCrossRefGoogle Scholar
  2. 2.
    J.B. Habib, C. Bossaller, S. Well, C. Willliams, J.D. Morrisett, P.D. Henry, Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbits by treatment with the calcium blocker PN 200110. Circulation Res 58:305–309 (1986).PubMedGoogle Scholar
  3. 3.
    T.J. Verbeuren, F.H. Jordaens, L.L. Zonnekeyn, C.E. Van Hove, M.C. Coene, A.G. Herman, Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Circulation Res 58:552–564 (1986).PubMedGoogle Scholar
  4. 4.
    P.C. Freiman, G.G. Mitchell, D.D. Heistad, M.L. Armstrong, and D.G. Harrison, Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates, Circ Res 58:783–789 (1986).PubMedGoogle Scholar
  5. 5.
    U. Förstermann, A. Mögge, U. Alheid, A. Haverich, and J.C. Frölich, Selective attenuation of endothelium-mediated vasodilation in atherosclerotic human coronary arteries, Circ Res 62:185–190 (1988).PubMedGoogle Scholar
  6. 6.
    D.D. Heistad, M.L. Armstrong, M. Marcus, D.J. Piegors, and A.L. Mark, Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys, Circ Res 54:711–718 (1984).PubMedGoogle Scholar
  7. 7.
    P.L. Ludmer, A.P. Selwyn, T.L. Shook, R.R. Wayne, G.H. Mudge, R.W. Alexander, and P. Ganz, Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries, N Engl J Med 315:1046–1051 (1986).PubMedCrossRefGoogle Scholar
  8. 8.
    A. Maseri, A. L’Abbate, G. Baroldi, S. Chierchia, M. Marzilli, A.M. Ballestra, S. Severi, O. Parodi, A. Biagini, A. Distante, and A. Pesola, Coronary vasospasm as a possible cause of myocardial infarction, N Engl J Med 299:1271–1277 (1978).PubMedCrossRefGoogle Scholar
  9. 9.
    J. Willerson, D. Hillis, M. Winniford, and L. Buja, Speculation regarding mechanisms responsible for acute ischemic heart disease syndrome, J Am Coll Cardiol 8:245–250 (1986).PubMedCrossRefGoogle Scholar
  10. 10.
    D.S. Houston, J.T. Shepherd, and P.M. Vanhoutte, Aggregating human platelets cause direct contraction and endothelium-dependent relaxation of isolated canine coronary arteries, J Clin Invest 78:539–544 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    J.A.G. Lopez, M. Armstrong, D. Piegors, and D.D. Heistad, Effect of early and advanced atherosclerosis on vascular responses to serotonin, thromboxane A2, and ADP, Circulation 79:698–705 (1989).PubMedCrossRefGoogle Scholar
  12. 12.
    W.M. Chilian, K.C. Dellsperger, S.M. Layne, C.L. Eastham, M.A. Armstrong, M.L. Marcus, and D.D. Heistad, Effects of atherosclerosis on the coronary circulation. Am J Physiol:Heart 27:H529–539 (1990).Google Scholar
  13. 13.
    J.K. Williams, G.L. Baumbach, M.L. Armstrong, D.D. Heistad, Hypothesis: Vasoconstriction contributes to amaurosis fugax, J Cereh Blood Flow Metab 9:111–116 (1989).CrossRefGoogle Scholar
  14. 14.
    J.A.G. Lopez, J.C. Hoak, M.L. Armstrong, D.J. Piegors, and D.D. Heistad, Effect of intravascular collagen in atherosclerotic primates, J Am Coll Cardiol (Abstract) 15:12A (1990).CrossRefGoogle Scholar
  15. 15.
    R.G. Gerrity, The role of the monocyte in atherogenesis. Transition of blood-borne monocytes into foam cells in fatty lesions. Am J Pathol 103:181–190 (1981).PubMedGoogle Scholar
  16. 16.
    J.A.G. Lopez, M.L. Armstrong, D.G. Harrison, D.J. Piegors, and D.D. Heistad, Vascular responses to leukocyte products in atherosclerotic primates, Circ Res 65;1078–1086 (1989).PubMedGoogle Scholar
  17. 17.
    M.G. Bond, M.R. Adams, and B.C. Bullock, Complicating factors in evaluating coronary artery atherosclerosis. Artery 9:21–29 (1981).PubMedGoogle Scholar
  18. 18.
    M.L. Armstrong, D.D. Heistad, M.L. Marcus, M.B. Megan, and D.J. Piegors, Structural and hemodynamic responses of peripheral arteries of macaque monkeys to atherogenic diet, Arteriosclerosis 5:336–346 (1985).PubMedCrossRefGoogle Scholar
  19. 19.
    S. Glagov, E. Weisenberg, C.K. Zarins, R. Stankunavicius,and G.J. Kolettis, Compensatory enlargement of human atherosclerotic coronary arteries, N Engl J Med 316:1371–1375 (1987).PubMedCrossRefGoogle Scholar
  20. 20.
    D.D. McPherson, L.F. Hiratzka, W.C. Lamberth, B. Brandt, M. Hunt, R. A. Kieso, M.L. Marcus, and R.E. Kerber, Delineation of the extent of coronary atherosclerosis by high frequency epicardial echocardiography, N Engl J Med 316:304–309 (1987).PubMedCrossRefGoogle Scholar
  21. 21.
    R. Guerra, Jr., A F.A. Brotherton, P.J. Goodwin, C.R. Clark, M.L. Armstrong, D.G. Harrison, Mechanisms of abnormal endothelium- dependent vascular relaxation in atherosclerosis: implications for altered autocrine and paracrine functions of EDRF, Blood Vessels 26:300–314 (1989).PubMedGoogle Scholar
  22. 22.
    H. Yasue, Y. Horio, N. Nakamura, H. Fujii, N. Imoto, R. Sonoda, K. Kugiyama, K. Obata, Y. Morikami, and T. Kimura, Induction of coronary artery spasm by acetylcholine in patients with variant angina: possible role of the paras3nattpathetic nervous system in the pathogenesis of coronary artery spasm. Circulation 74:955–963 (1986).PubMedCrossRefGoogle Scholar
  23. 23.
    G.L. Baumbach and D.D. Heistad, Remodeling of cerebral arterioles in chronic hypertension. Hypertension 13:968–972 (1989).PubMedGoogle Scholar
  24. 24.
    T.F. Luseher and P.M. Vanhoutte, Endothelium-dependent contractions to acetylcholine in the aorta of the spontaneously hjrpertensive rat. Hypertension 8:334–348 (1986).Google Scholar
  25. 25.
    W.G. Mayhan, F.M. Faraci, and D.D. Heistad, Impairment of endothelium-dependent responses of cerebral arterioles in chronic hypertension. Am J Physiol: Heart Circ Physiol 22:H1435-H1440 (1987).Google Scholar
  26. 26.
    W.G. Mayhan, F.M. Faraci, and D.D. Heistad, Responses of cerebral arterioles to adenosine 5’-diphosphate, serotonin, and the thromboxane analogue U-46619 during chronic hypertension. Hypertension 12:556–561 (1988).PubMedGoogle Scholar
  27. 27.
    M. Armstrong, D. Heistad, M. Marcus, D.J. Piegors, and F.M. Abboud, Hemodynamic sequelae of regression of experimental atherosclerosis, J Clin Invest 71:104–113 (1983).PubMedCrossRefGoogle Scholar
  28. 28.
    D. Vesselinovitch and R.W. Wissler, Reversal of atherosclerosis: comparison of nonhuman primate models. In: “Atherosclerosis V,” Gotto AM Jr., Smith LC and Allen B, eds., Springer-Verlag, New York (1980).Google Scholar
  29. 29.
    D.D. Heistad, A.L. Mark, M.L. Marcus, D.J. Piegors, and M.L. Armstrong, Dietary treatment of atherosclerosis abolishes h3rperresponsiveness to serotonin: Implications for vasospasm, Circ Res 61:346–351 (1987).PubMedGoogle Scholar
  30. 30.
    D.G. Harrison, M.L. Armstrong, P.C. Freiman, and D.D. Heistad, Restoration of endothelium-dependent relaxation by dietary treatment of atherosclerosis, J Clin Invest 80:1808–1811 (1987).PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Donald D. Heistad
    • 1
  • J. Antonio G. Lopez
    • 1
  • Frank M. Faraci
    • 1
  • Mark L. Armstrong
    • 1
  1. 1.Department of Internal MedicineVA Medical Center and University of Iowa College of MedicineIowa CityUSA

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