Platelet Labelling in Atherosclerosis

  • Helmut Sinzinger
  • Irene Virgolini
  • Peter Fitscha
Part of the Nato ASI Series book series (NSSA, volume 219)


Three mechanisms are centrally involved in human atherogenesis, i.e., the role of the coagulation system: encrustation theory (C. von Rokitansky 1), cellular reaction to injury (Virchow 2), and lipid entry (Anitschkow 3) are well defined. Bizzozero (4) more than one century ago stressed the role of platelets. In recent years the early diagnosis of atherosclerosis using radioisotopic techniques has been frequently attempted. The most extensive information available concerns the involvement of the coagulation system using radiolabelling of either fibrinogen or platelets. In this brief overview all three of these processes of atherogenesis will be considered with special attention to use of labelled platelets. At present atherosclerosis can be functionally monitored at least partially to permit further insights into the development of the disease, but there are still limitations to be overcome.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Helmut Sinzinger
    • 1
    • 2
    • 3
  • Irene Virgolini
    • 1
    • 2
    • 3
  • Peter Fitscha
    • 1
    • 2
    • 3
  1. 1.Atherosclerosis Research Group (ASF)ViennaAustria
  2. 2.Atherosclerosis Research Group of the Austrian Academy of SciencesViennaAustria
  3. 3.2nd Department of Internal MedicinePoliclinic ViennaAustria

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