The Use of Radiolabeled Low Density Lipoprotein for Evaluating Atherosclerosis: Present Status and Future Promise
Emerging noninvasive techniques such as magnetic resonance imaging, vascular ultrasound, and synchrotron angiography promise in vivo detection and analysis of atherosclerosis in ways that could only be imagined a decade ago. Conventional invasive arteriography, verified whenever possible by dissection and lesion component morphometry, remains the gold standard for revealing atheroma location and lesion-associated stenosis. Yet the newer modalities are acquiring the power and the resolution that may permit accurate assessment of plaque size and shape; of spatial disposition of lipid, mineral, and tissue components within a plaque; and of structural distortions and adaptations in the artery wall adjacent to an atherosclerotic lesion.
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