How an Understanding of HDL’s Metabolism May Help us Discover New Ways to Evaluate Atherosclerosis and its Risk of Progression in the Living Patient

  • Gerd Assmann
Part of the Nato ASI Series book series (NSSA, volume 219)


Prospective studies of recent years have demonstrated the existence of a reverse relation between plasma HDL (high density lipoproteins) concentration and the incidence of coronary artery disease (1–3) (Table 1). Also, in cohort studies patients with verified coronary artery disease present with lower mean HDL concentrations than healthy controls (Figure 1). A study group of the European Atherosclerosis Society (EAS) has, in a recent policy statement (4), agreed on 35 mg/dl HDL cholesterol as a provisional cutoff value for risk assessment. This cutoff corresponds to the 16th percentile of the HDL cholesterol distribution in adult males in West Germany (Figure 2). Plasma concentrations below this cutoff may be associated with increased risk for premature onset of atherosclerosis.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Gerd Assmann
    • 1
  1. 1.Institut für Klinische Chemie und Laboratoriumsmedizin und Institut for ArterioskleroseforschungMünsterGermany

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