B-Mode Ultrasound Imaging Characterization of Atherosclerosis

  • M. Mercuri
  • M. G. Bond
  • H. L. Strickland
  • W. J. Bo
  • C. P. Purvis
  • V. Challa
Part of the Nato ASI Series book series (NSSA, volume 219)


At present, prevention of atherosclerosis, or the effective inhibition of the lesion progression, remains a primary medical research objective (1). In the past 50 years efforts have been made to study and understand the atherosclerotic process, and have resulted in several achievements in basic sciences, epidemiology and medical management of the disease. Using experimental and animal models, specific therapies have been developed and tested and offer promising perspectives. However, it would be of great help to detect the morphological characteristics of atherosclerosis non-invasively and during plaque evolution in human arteries.


Atherosclerotic Plaque Carotid Plaque Ultrasonic Image Fibrous Plaque Bogalusa Heart Study 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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  1. 1.
    D. E. Strandness, Workshop overview, in: Clinical Diagnosis of Atherosclerosis, M. G. Bond, W. Insull, S. Glagov, A. B. Chandler and J.F. Cornhill, eds., p. 1, Springer-Verlag Inc., New York (1982).Google Scholar
  2. 2.
    J. F. Greenleaf, Tissue Characterization with Ultrasound, CRC Press Inc., Boca Raton (FL) (1986).Google Scholar
  3. 3.
    R. B. Rutherford, Evaluation and selection of patients for vascular surgery, in: Vascular Surgery, R. B. Rutherford, ed., p. 11, W.B. Saunders Co., Philadelphia (1989).Google Scholar
  4. 4.
    P. Pignoli, E. Tremoli, A. Poli, P. Oreste, and R. Paoletti, Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging. Circulation 74:1399 (1986).PubMedCrossRefGoogle Scholar
  5. 5.
    W. A. Riley, D. S. Freedman, N. A. Higgs, R. W. Barnes, S. A. Zinkgraf, and G. S. Berenson, Decreased arterial elasticity associated with cardiovascular disease risk factors in the young, Bogalusa Heart Study, Arteriosclerosis 6:378 (1986).PubMedCrossRefGoogle Scholar
  6. 6.
    M. G. Bond, K. S. Wilmoth, G. L. Enevold, and H. L. Strickland, Detection and monitoring of asymptomatic atherosclerosis in clinical trials. Am J Med 86(suppl. 4A):33 (1989).PubMedCrossRefGoogle Scholar
  7. 7.
    J. J. Ricotta, F. A. Bryan, M. G. Bond, A. Kurtz, D. H. O’Leary, J. K. Raines, A. S. Berson, M. E. Clouse, M. Calderon-Ortiz, J. F. Toole, J. A. DeWeese, S. N. Smullens, and N. F. Gustafson, Multicenter validation study of real-time (B-Mode) ultrasound, arteriography, and pathologic examination, J Vase Surg 6:512 (1987).Google Scholar
  8. 8.
    D. E. Strandness, Ultrasound in the study of atherosclerosis. Ultrasound in Med & Biol 12:453 (1986).CrossRefGoogle Scholar
  9. 9.
    C. K. Zarins and S. Glagov, Artery wall pathology in atherosclerosis, in: R.B. Rutherford, Vascular Surgery, p. 178, W.B. Saunders Co., Philadelphia (1989).Google Scholar
  10. 10.
    L. M. Reilly, R. J. Lusby, L. Hughes, L. D. Ferrel, R. J. Stoney, and W. R. Ehrenfeld, Carotid plaque histology using real-time ultrasonography, Am J Surg 146:188 (1983).PubMedCrossRefGoogle Scholar
  11. 11.
    E. I. Bluth, D. Kay, C. R. B. Merrit, M. Sullivan, G. Farr, N. L. Mills, M. Foreman, K. Sloan, M. Schlater, and J. Stewart, Sonographic characterization of carotid plaque: Detection of hemorrhage, AJR 146:1061 (1986).PubMedGoogle Scholar
  12. 12.
    J. Weinberger, S. J. Marks, J. J. Gaul, B. Goldman, H. Schanzer, J. Jacobson, and S. Dikman, Atherosclerotic plaque at the carotid artery bifurcation. Correlation of ultrasonographic imaging with morphology, J Ultrasound Med 6:363 (1987).PubMedGoogle Scholar
  13. 13.
    B. Barzilai, J. E. Saffitz, J. G. Miller, and B. E. Sobel, Quantitative ultrasonic characterization of the nature of atherosclerotic plaques in human aorta. Circulation Research 60:459 (1987).PubMedGoogle Scholar
  14. 14.
    E. Picano, L. Landini, F. Lattanzi, C. Michelassi, M. Salvadori, F. Santarelli, A. Distante, A, L’Abbate, Ultrasonic tissue characterization of atherosclerosis: State of the art 1988, J Nucl Med & Allied Sciences 32:174 (1988).Google Scholar
  15. 15.
    Statgraphics: Statistical graphic system. Statistical Graphic Corporation, New York (1986).Google Scholar
  16. 16.
    M. W. Higgins and A. R. Sharrett, Ultrasound measurement of atherosclerosis: Directions for epidemiology, in: Pathobiology of the Human Atherosclerotic Plaque, p. 899, S. Glagov, W. P. Newmann, III and S. A. Shaffer, eds., Springer-Verlag, New York (1990).CrossRefGoogle Scholar
  17. 17.
    D. J. Skorton, R. C. Chivers and S. M. Collins, Ultrasonic tissue characterization in cardiology. Am J Noninvas Cardiol 1:88 (1987).Google Scholar
  18. 18.
    S. M. Collins and D. J. Skorton, Computers in Cardiac Imaging. JACC 9:669 (1987).PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. Mercuri
    • 1
    • 3
  • M. G. Bond
    • 1
  • H. L. Strickland
    • 1
  • W. J. Bo
    • 1
  • C. P. Purvis
    • 1
  • V. Challa
    • 2
  1. 1.Division of Vascular Ultrasound Research, Department of Neurobiology and Anatomy, and Stroke Research CenterBowman Gray School of MedicineWinston-SalemUSA
  2. 2.Department of Pathology, and Stroke Research CenterBowman Gray School of MedicineWinston-SalemUSA
  3. 3.II Department of Internal MedicineUniversity of PerugiaPerugiaItaly

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