Transvenous Coronary Angiography with Synchrotron Radiation

  • E. Rubenstein
Part of the Nato ASI Series book series (NSSA, volume 219)


X-ray-based angiography continues to be the standard method of assessing the severity and the extent of coronary atherosclerosis. The relative insensitivity of conventional X-ray imaging systems to iodine-containing contrast agents necessitates that the images be acquired with essentially undiluted contrast agent in the lumen of the vessels being studied. This, in turn, requires arterial catheterization and the insertion of the catheter tip in or near the ostia of the vessels and the direct injection of the contrast agent. The health risks and monetary costs of the procedure have limited its use to circumstances in which there is a high probability of the presence of severe disease. Despite these problems, coronary angiography has been employed in serial studies to evaluate the effects of drug therapy and diet on coronary atherosclerosis (1).


Contrast Agent Left Anterior Descend Synchrotron Radiation Left Internal Mammary Artery Electron Storage Ring 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    See chapter by D. M. Kramsch, this publication.Google Scholar
  2. 2.
    B. Jacobson, Dichromatic absorption radiography. Dichromography, Acta. Radiol. 39:437 (1953).PubMedCrossRefGoogle Scholar
  3. 3.
    E. Rubenstein, E.B. Hughes, L.E. Campbell, R. Hofstadter, R.L. Kirk, T.J. Krolocki, J.P. Stone, S. Wilson, H.D. Zeman, W.R. Brody, A. Macovski, A.C. Thompson, Synchrotron radiation and its application to digital subtraction, SPIE 314:42 (1981).Google Scholar
  4. 4.
    H. Winick, A. Bienenstock, Synchrotron radiation research, Ann. Rev. Nucl. Part. Sci 28:33 (1978).CrossRefGoogle Scholar
  5. 5.
    E.B. Hughes, H.E. Zeman, L.E. Campbell, R. Hofstadter, U. Meyer-Berkhout, J.N. Otis, J. Rolfe, J.P. Stone, S. Wilson, E. Rubenstein, D.C. Harrison, R. S. Kernoff, A.C. Thompson, and G.S. Brown, The application of synchrotron radiation to non-invasive angiography, Nuc. Instru. Methods Phys. Res. 208:665 (1983).CrossRefGoogle Scholar
  6. 6.
    H.D. Zeman, E.B. Hughes, L. Finman Campbell, R. Hofstadter, A. Hudson, J.N. Otis, J. Rolfe, E. Rubenstein, D.C. Harrison, R.S. Kernoff, A.C. Thompson, and G.S. Brown, Evaluation of synchrotron x-rays for transvenous coronary angiography, Nuc. Instru. Methods Phys. Res. 222:308 (1984).CrossRefGoogle Scholar
  7. 7.
    E.B. Hughes, E. Rubenstein, H.D. Zeman, G.S. Brown, M. Buchbinder, D.C. Harrison, R. Hofstadter, R.S. Kernoff, J.N. Otis, H.A. Sommer, A.C. Thompson, J.T. Walton, Prospects for non-invasive angiography with tunable x-rays, Nuc. Instru. Methods Phys. Res. B10/ll:323 (1985).CrossRefGoogle Scholar
  8. 8.
    E.B. Hughes, Rubenstein, E., Zeman, H.D., Brown, G.S., Buchbinder, M, Harrison, D.C., Hofstadter, R.S., Otis, J.N., A.C. Thompson, The angiography program at Stanford, Nuc. Instru. Methods Phys. Res. A246:719 (1986).CrossRefGoogle Scholar
  9. 9.
    A.C. Thompson, H.D. Zeman, E. Rubenstein, J.N. Otis, R.H. Hofstadter, G.S. Brown, D.C. Harrison, R.S. Kernoff, J.C. Giacomini, H.J. Gordon, W. Thomlinson, Transvenous coronary angiography in dogs using Synchrotron radiation, Internat. J. Cardiac Imag. 2:53 (1986).CrossRefGoogle Scholar
  10. 10.
    E. Rubenstein, R. Hofstadter, H.D. Zeman, A.C. Thompson, J.N. Otis, G.S. Brown, J.C. Giacomini, H.J. Gordon, R.S. Kernoff, D.C. Harrison, W. Thomlinson, Transvenous coronary angiography in humans using synchrotron radiation, Proc. Nat. Acad. Sci. 83:9724 (1986).PubMedCrossRefGoogle Scholar
  11. 11.
    A. Thompson, R. Hofstadter, J.N. Otis, H.D. Zeman, R.S. Kernoff, E. Rubenstein, J.C. Giacomini, H.J. Gordon, G.S. Brown, W. Thomlinson, Transvenous coronary angiography using synchrotron radiation, Nuc. Instru. Methods Phys. Res. A266, 252 (1988).CrossRefGoogle Scholar
  12. 12.
    E. Rubenstein, J.C. Giacomini, H.J. Gordon, A.C. Thompson, G.S. Brown, R. Hofstadter, W. Thomlinson, H.D. Zeman, Synchrotron radiation coronary angiography with a dual beam, dual detector imaging system, Nuc. Instru. Methods Phys. Res. (in press).Google Scholar
  13. 13.
    E. Ebashi, E. Rubenstein, M. Koch, “Handbook on Synchrotron Radiation” Volume 4, North-Holland Physics Publishing, Amsterdam (in press, 1990).Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • E. Rubenstein
    • 1
  1. 1.Stanford University School of MedicineStanfordUSA

Personalised recommendations