Atherosclerosis: A Moving Target Key Note Presentation

  • Henry C. McGillJr.
Part of the Nato ASI Series book series (NSSA, volume 219)


It is gratifying the see the effort and attention given here to the issue of evaluating atherosclerotic lesions, especially atherosclerosis in living persons. Pathologists who have examined the arteries of autopsied persons for many years have longed for the opportunity to observe the movement of the process. In attempts to describe that movement, we have had to reconstruct the process by measuring various qualities of the lesions in large numbers of autopsied persons, and arranging the values in age sequence.


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  1. Katz, S.S., 1981, The lipids of grossly normal human aortic intima from birth to old age. J. Biol. Chem. 23:12275–12280.Google Scholar
  2. Libby, P., Warner, S.J.C., and Friedman, G.B., 1988, Interleukin-1: a mitogen for human vascular smooth muscle cells that induces the release of growth inhibitory prostanoids, J. Clin. Invest. 88:487–498.CrossRefGoogle Scholar
  3. Libby, P., Salomon, R.N., Payne, D.D., Schoen, F.J., and Pober, J.S., 1989, Functions of vascular wall cells related to the development of transplantation-associated coronary arteriosclerosis. Transplantation Proc. 21:3677–3684.Google Scholar
  4. McGill, H.C., Jr., 1988, The pathogenesis of atherosclerosis. Clin. Chem. 33:833–839.Google Scholar
  5. McGill, H.C., Jr., Geer, J.C., and Strong, J.P., 1963, Natural history of human atherosclerotic lesions, in “Atherosclerosis and Its Origin,” M. Sandler and G.H. Bourne, eds. Academic Press, New York.Google Scholar
  6. Melnick, J.L., Adam, E., and DeBakey, M.E., 1990, Possible role of cytomegalovirus in atherogenesis. JAMA 263:2204–2207.CrossRefGoogle Scholar
  7. Pober, J.S. and Cotran, R.S., 1990. Cytokines and endothelial cell biology. Physiol. Rev. 70:427–451.CrossRefGoogle Scholar
  8. Ross, R., Masuda, J., Raines, E.W., Gown, A.M., Katsuda, S., Sasahara, M., Maiden, L.T., Masuko, H., and Sato, H., 1990, Localization of PDGF-B protein in macrophages in all phases of atherogenesis. Science 248:1009–1012.CrossRefGoogle Scholar
  9. Stary, H.C., 1989, Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis (Supp. I) 9:1–19-1–32.Google Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Henry C. McGillJr.
    • 1
  1. 1.Department of PathologyUniversity of Texas Health Science Center and the Southwest Foundation for Biomedical ResearchSan AntonioUSA

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