Drug Therapy as an Aspect of Ecological Genetics

  • D. A. P. Evans


Human beings have been subjected to many changes in their environment in the last century and most of these cannot be accurately defined and quantified. However, a fairly recent one which can be studied with some precision relates to the fact that about half the population now consumes some type of drug medication more or less regularly.


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  1. Armaly M.F. (1963a) Effect of corticosteroids on intraocular pressure and fluid dynamics I the effect of dexamethasone in the normal eye. Archs. Ophthal. N. Y. 70, 482–491.CrossRefGoogle Scholar
  2. Armaly M.F. (1963b) Effect of corticosteroids on intraocular pressure and fluid dynamics. II the effect of dexamethasone in the glaucomatous eye. Archs Ophthal N. Y. 70, 492–499.CrossRefGoogle Scholar
  3. Armaly M.F. (1965) Statistical attributes of the steroid hypertensive response in the clinically normal eye. I the demonstration of three levels of response. Invest. Ophthal. 4, 187–197.PubMedGoogle Scholar
  4. Armaly M.F. (1966a) Dexamethasone ocular hypertension in the clinically normal eye. II The untreated eye outflow facility and concentration. Archs. Ophthal. N. Y. 75, 776–782.CrossRefGoogle Scholar
  5. Armaly M.F. (1966b) The heritable nature of dexamethasone-induced ocular hypertension. Archs. Ophthal. N. Y. 75, 32–35.CrossRefGoogle Scholar
  6. Armaly M.F. (1967a) Inheritance of dexamethasone hypertension and glaucoma. Archs Ophthal. N. Y. 77, 747–751.CrossRefGoogle Scholar
  7. Armaly M.F. (1967b) The genetic determination of ocular pressure in the normal eye. Archs Ophthal. N. Y. 78, 187–192.CrossRefGoogle Scholar
  8. Armaly M.F. (1967c) Dexamethasone ocular hypertension and eosinopenia and glucose tolerance test. Archs Ophthal. N. Y. 78, 193–197.CrossRefGoogle Scholar
  9. Armaly M.F. (1968) Genetic factors related to glaucoma. Ann. N.Y. Acad. Sci. 151, 861–875.CrossRefGoogle Scholar
  10. Armaly M.F., Montstavicius B.F. & Sayegh R.E. (1968) Ocular pressure and aqueous outflow facility in siblings. Archs Ophthal. N. Y. 80, 350–360.CrossRefGoogle Scholar
  11. Armstrong J.R., Daily R.K., Dobson H.H. & Girard L.J. (1960) The incidence of glaucoma in diabetes mellitus. Am. J. Ophthal. 50, 55–63.CrossRefGoogle Scholar
  12. Becker B. & Mills D.W. (1963) Corticosteroids and intraocular pressure. Archs Ophthal N. Y. 70, 500–507.CrossRefGoogle Scholar
  13. Becker B. (1964) The effect of topical corticosteroids in secondary glaucomas. Archs Ophthal N. Y. 72, 769–771.CrossRefGoogle Scholar
  14. Becker B. & Hahn K. A. (1964) Topical corticosteroids and heredity in primary open angle glaucoma. Am. J. Ophthal 57, 543–551.CrossRefGoogle Scholar
  15. Becker B., Bresnick G., Chevrette L., Kolker A.E., Oaks M. & Cibis M. (1966) Intraocular pressure and its response to topical corticosteroids in diabetics. Archs Ophthal N. Y. 76, 477–483.CrossRefGoogle Scholar
  16. Becker B. & Ramsey C.K. (1970) Plasma Cortisol and the intraocular pressure response to topical corticosteroids. Am. J. Ophthal. 69, 999–1002.CrossRefGoogle Scholar
  17. Brück H., Fearnley M.E., Meanock I. & Patley H. (1954) Phenylbutazone therapy: relation between the toxic and therapeutic effects and the blood level. Lancet I, 225–228.CrossRefGoogle Scholar
  18. Chrishansson J. (1961) Intraocular pressure in diabetes mellitus. Acta ophthal 39, 155.CrossRefGoogle Scholar
  19. Ford E.B. (1965) Genetic Polymorphism, p. 87. Faber and Faber, London.Google Scholar
  20. Fouts J.R. (1961) The metabolism of drugs by subfractions of hepatic microsomes. Biochem. biophys. Res. Commun. 6, 373–378.CrossRefGoogle Scholar
  21. François J. (1961) Glaucome apparemment simple secondaire à la cortisonotheràpie locale. Ophthalmologic, Basel 142, 517–523.Google Scholar
  22. Galton F. (1889) Natural Inheritance. Macmillan, London.CrossRefGoogle Scholar
  23. Goldmann H. (1962) Cortisone glaucoma. Archs Ophthal. N. Y. 68, 621–626.CrossRefGoogle Scholar
  24. Grant W.M. (1964) Glaucoma Research Conference. Am. J. Ophthal 58, 1065.CrossRefGoogle Scholar
  25. Harris H. (1966) Enzyme polymorphisms in Man. Proc. R. Soc. B 164, 298–310.CrossRefGoogle Scholar
  26. Harris H. (1969) Genes and Isozymes. Proc. R. Soc. B174, 1–31.CrossRefGoogle Scholar
  27. Levene R.Z. & Schwartz B. (1968) Depression of plasma Cortisol and the steroid ocular pressure response. Archs Ophthal N. Y. 80, 461–466.CrossRefGoogle Scholar
  28. Levi A. J., Sherlock S. & Walker D. (1968) Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy. Lancet 1, 1275–1279.CrossRefGoogle Scholar
  29. Robson J.M. & Stacey R.S. (1968) Recent advances in pharmacology; 4th edn., p. 34. Churchill, London.Google Scholar
  30. Rosenbaum L.J., Alton E. & Becker B. (1970) Dexamethasone testing in Southwestern Indians. Invest. Ophthal. 9, 325–330.PubMedGoogle Scholar
  31. Safir A., Paulsen E.P. & Klayman J. (1964) Elevated intraocular pressure in diabetic children. Diabetes 13, 161–163.CrossRefGoogle Scholar
  32. Stern J.J. (1953) Acute glaucoma during cortisone therapy. Am. J. Ophthal 36, 389–390.CrossRefGoogle Scholar
  33. Trevor-Roper P.D. (1962) Ophthalmology. A Textbook for Diploma Students, p. 512. Lloyd-Luke, London.Google Scholar
  34. Vesell E.S. & Page J.G. (1968) Genetic control of drug levels in Man: phenylbutazone. Science 159, 1479–1480.CrossRefGoogle Scholar
  35. Whittaker J. W. & Evans D. A.P. (1970) Genetic control of phenylbutazone metabolism in Man. Br. med. J. 4, 323–328.CrossRefGoogle Scholar

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© Blackwell Scientific Publications 1971

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  • D. A. P. Evans

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