The Molecular Basis of Thalassaemia
In his monograph Genetic Polymorphism, E.B. Ford (1965) discussed the sickle-cell mutation as a model system for examining the phenomena of balanced polymorphism in human genetics. The haemoglobinopathies remain a valuable tool for the study of gene action in Man but in the last few years the emphasis in this field has changed from population genetics to the study of abnormal haemoglobin synthesis at a molecular level. This trend is particularly noticeable in recent work on thalassaemia.
KeywordsPeptide Chain Translation Time Foetal Haemoglobin Chain Initiation Globin Chain
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