Organic Peroxy Free Radicals and the Role of Superoxide Dismutase and Antioxidants
When a biological system is exposed to free radicals, clearly a large number of different molecules will be affected. Some of these molecules may be important, for example DNA or perhaps a key protein whose normal rate of synthesis is comparatively slow. The repercussions may then be serious. If other molecules are affected this may be less important: destruction of a small amount of glucose, for example, is unlikely to effect a biological system per se. Of course, there does remain the possibility that stable or free radical products derived from such harmless substances may themselves be toxic. It must not be forgotten that when a free radical reacts with an organic molecule, another free radical is usually formed. The reactions of this radical must then be taken into account.
KeywordsHydrogen Transfer Free Radical Reaction Peroxy Radical Pulse Radiolysis Free Radical Damage
Unable to display preview. Download preview PDF.
- Willson, R.L., 1977, Iron, zinc, free radicals and oxygen in tissue disorders and cancer control, Ciba Foundation, Symp. 51. Iron Metabolism, Elsevier/Excerpta Medica North Holland, pp. 331.Google Scholar
- Willson, R.L., 1985, Organic peroxy free radicals as ultimate agents in oxygen toxicity, in “Oxidative Stress,” H. Sies, ed., pp. 41–72, Academic Press, London.Google Scholar
- Willson, R.L., Dunster, C.A., Forai, L.G., Gee, C.A., and Kittridge, C.A., 1985, Organic free radicals and proteins in biochemical injury: electron or hydrogen transfer reactions?, Phil. Trans. R. Soc. Lond., B311:545.Google Scholar