Oxidative and Peroxidative Damage and its Role in the Aging Process
Aging is a phenomenon marked by a progressive decline with time of the capacity of the organism, or given component systems in it, to respond to environmental challenges. This phenomenon can be associated with the accumulation of alterations in structure, composition and function of cells, tissues and organs of multicellular organisms. Aging organisms thus characteristically exhibit a time-associated increase in the propensity to die. Death ensues when one or several activities necessary for the maintenance of viability of cellular or organ systems decline below a critical level. This can happen randomly in any one of an assortment of tissue or organ systems which are essential for the viability of the whole organism (e.g., the brain, heart or lung systems).
KeywordsLife Span Glutathione Reductase Active Oxygen Species Phosphatidyl Ethanolamine Peroxidative Damage
Unable to display preview. Download preview PDF.
- Brot, N., and Weissbach, H., April 1982, Trens Bioch. Sci., 137–139.Google Scholar
- Epstein, J., and Gershon, D., 1972, Mech. Age. Dev., 1:257.Google Scholar
- Glass, G.A., Gershon, D., and Gershon, H., 1985, Exp. Hematol.. Google Scholar
Truscott, R. J.W., and Augusteyn, R.C., 1977, Bioch. Biophys. Acta, 492:43. RECOMMENDED READING
- Lippman, R.D., 1983, Lipid peroxidation and metabolism in aging: a biological, chemical and medical approach, Review of Biological Research in Aging, 1:315, Alan Liss Inc.Google Scholar
- Sohal, R.S., ed., “Age Pigments”, 1981, Elsevier/North Holland.Google Scholar
- Wolff, S.P., Garner, A., and Dean, R.T., January 1986, Free radicals, lipids and protein degradation, Trends Bioch. Sci., 27–31.Google Scholar