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Oxidative Effects of Physical Exercise

  • Alexandre T. Quintanilha

Abstract

Increased physical activity in animals is accompanied by significantly higher rates of oxygen consumption (see Brooks & Fahey, 1984); in man these increases can be of the order of ten-fold. While the biological toxicity of oxygen was already known to Lavoisier and Priestley and has been clearly demonstrated for animals at higher pressures (> 1 atmosphere) and at higher concentrations (> 20%), less attention has been paid to the effect of higher rates of consumption. For flying insects (Sohal, 1981) several interesting studies have clearly established a positive correlation between higher rates of oxygen consumption (due to increased physical activity) and a shorter life span (accompanied by a faster rate of accumulation of oxidative products of lipids and proteins). In mammals such a correlation has not been established, perhaps for the simple reason that the increase in the rate of oxygen consumption of mammals at the onset of exercise is significantly smaller than in flying insects.

Keywords

Electron Spin Resonance Physical Exercise Total Glutathione Glutathione Disulfide Sedentary Animal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Aikawa, K.M., Quintanilha, A.T., deLumen, B.O., Brooks, G.A., and Packer, L., 1984, Bioscience Reports, 4:253.PubMedCrossRefGoogle Scholar
  2. Armstrong, R.B., Laughlin, M.H., Rowe, L., and Taylor, C.R., 1983, J. Appl. Physiol, 55:518.PubMedGoogle Scholar
  3. Asmussen, E., 1956, Acta Rheumatol. Scand., 2:109.PubMedGoogle Scholar
  4. Brooks, G.A., and Fahey, T.D., 1984, “Exercise Physiology: Human Bioenergetics and Its Applications,” John Wiley & Sons, New York.Google Scholar
  5. Davies, C.T.M., and White, M.J., 1981, Pfluegers Arch., 392:168.CrossRefGoogle Scholar
  6. Davies, K.J.A., Quintanilha, A.T., Brooks, G.A., and Packer, L., 1982, Biochem. Biophys. Res. Commun., 107:1198.PubMedCrossRefGoogle Scholar
  7. Friden, J., Sjöström, M., and Ekblom, B., 1983, Int. J. Sports Med., 4:170.PubMedCrossRefGoogle Scholar
  8. Highman, B., and Altland, P.D., 1963, Am. J. Physiol., 205:162.PubMedGoogle Scholar
  9. Hough, T., 1902, Am. J. Physiol., 7:76.Google Scholar
  10. Kaplowitz, N., Aw, T.Y., and Ookhtens, M., 1985, Ann. Rev. Pharmacol., 25:715.CrossRefGoogle Scholar
  11. Kasperek, G.J., Dohm, G.L., Barakat, H.A., Strausbach, P.H., Barnes, O.W., and Snider, R.D., 1982, Biochem. J., 202:281.PubMedGoogle Scholar
  12. Kasperek, G.J., Dohm, G.L., Tapscott, E.P., and Powell, T., 1980, Proc. Soc. Exp. Biol. Med., 164:430.PubMedGoogle Scholar
  13. Kossower, N.S., and Kossower, E.M., 1978, Int. Rev. Cytol., 54:109.CrossRefGoogle Scholar
  14. Larsson, A., Orrenius, S., Holmgren, A., and Mannervik, B., eds., 1978, “Functions of GSH,” Raven Press, New York.Google Scholar
  15. Lew, H., Pyke, S., and Quintanilha, A., 1987, J. Bioelectrochem., (in press).Google Scholar
  16. Lew, H., Pyke, S., and Quintanilha, A., 1985, FEBS Lett, 185:262.PubMedCrossRefGoogle Scholar
  17. McCully, K.K., 1986, Fed. Proc., 45:2933.PubMedGoogle Scholar
  18. Meister, A., and Anderson, M.E., 1983, Ann. Rev. Biochem., 52:711.PubMedCrossRefGoogle Scholar
  19. Newman, D.J., Jones, D.A., and Edwards, R.H.T., 1983a, Muscle Nerve, 6:380.CrossRefGoogle Scholar
  20. Newman, D.J., Mills, K.R., Quigley, B.M., and Edwards, R.H.T., 1983b, Clin. Sci., 64:55.Google Scholar
  21. Pyke, S., Lew, H., and Quintanilha, A., 1986, Biochem. Biophys. Res. Commun., 139:926.PubMedCrossRefGoogle Scholar
  22. Sies, H., and Graf, P., 1985, Biochem. J., 226:545.PubMedGoogle Scholar
  23. Sies, H., and Wendel, A., eds., 1978, “Functions of GSH in Liver and Kidney,” Springer-Verlag, New York.Google Scholar
  24. Sohal, R.S., 1981, “Age Pigments,” Elsevier, Amsterdam.Google Scholar
  25. Vihko, V., Rantamäki, and Salminen, A., 1979, J. Appl. Physiol. Respirat. Environ. Exercise Physiol., 47:43.Google Scholar
  26. Vihko, V., Rantamäki, and Salminen, A., 1978, Histochemistry, 57:237.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • Alexandre T. Quintanilha
    • 1
    • 2
  1. 1.Applied Science Division, Lawrence Berkeley LaboratoryUniversity of CaliforniaBerkeleyUSA
  2. 2.Physiology-Anatomy DepartmentUniversity of CaliforniaBerkeleyUSA

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