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Principles and Methods in the Study of Free Radicals Generated in the Metabolism and Cytotoxic Action of Chemotherapeutic Agents

  • J. William Lown

Abstract

Increasingly, the design, synthesis, selection and application of anticancer agents in chemotherapy is being replaced on a less empirical and more rational basis as a result of the detailed examination of mechanisms of action (Neidle and Waring, 1983; Pratt and Ruddon, 1979; Lown, 1982). It is becoming apparent that most agents exhibit several parallel pathways or effects on sensitive cell targets which include nucleic acids, certain proteins and membranes (Neidle and Waring 1982; Pryor, 1971).

Keywords

Anticancer Agent Pulmonary Toxicity Strand Breakage Free Radical Species Glycopeptide Antibiotic 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. William Lown
    • 1
  1. 1.Department of ChemistryUniversity of AlbertaEdmontonCanada

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