Principles and Methods in the Study of Free Radicals Generated in the Metabolism and Cytotoxic Action of Chemotherapeutic Agents

  • J. William Lown


Increasingly, the design, synthesis, selection and application of anticancer agents in chemotherapy is being replaced on a less empirical and more rational basis as a result of the detailed examination of mechanisms of action (Neidle and Waring, 1983; Pratt and Ruddon, 1979; Lown, 1982). It is becoming apparent that most agents exhibit several parallel pathways or effects on sensitive cell targets which include nucleic acids, certain proteins and membranes (Neidle and Waring 1982; Pryor, 1971).


Anticancer Agent Pulmonary Toxicity Strand Breakage Free Radical Species Glycopeptide Antibiotic 
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Copyright information

© Plenum Press, New York 1988

Authors and Affiliations

  • J. William Lown
    • 1
  1. 1.Department of ChemistryUniversity of AlbertaEdmontonCanada

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